Team uses exosomes to deliver Parkinson meds directly to brain
May 05, 2015
Researchers at the University of North Carolina at Chapel Hill have used exosomes from immune cells and successfully loaded them with the enzyme catalase, a potent antioxidant that counters the neuron-killing inflammation responsible for Parkinson and other degenerative neurologic disorders. Their work was published in the Journal of Controlled Release.
How deep-brain stimulation reshapes neural circuits in Parkinson disease
Apr 12, 2015
UC San Francisco scientists have discovered a possible mechanism for how deep-brain stimulation exerts its therapeutic effects. The new research, published online today in Nature Neuroscience, reveals that deep-brain stimulation keeps Parkinson disease symptoms in check by reducing excessive synchronization of brain activity in the motor cortex.
Mood, anxiety disorders common in Tourette patients, emerge at a young age
Mar 10, 2015
A new study of Tourette syndrome led by researchers from UC San Francisco and Massachusetts General Hospital has found that nearly 86% of patients who seek treatment for Tourette syndrome will be diagnosed with a second psychiatric disorder during their lifetimes, and that nearly 58% will receive 2 or more such diagnoses.
New information on Parkinson disease: GDNF not needed by midbrain dopamine system
Mar 04, 2015
A new study proves that the complete absence of glial cell-derived neurotrophic factor (GDNF) does not cause significant changes to the amount or function of dopamine neurons, reversing the findings of an article published in Nature Neuroscience in 2008.
Levodopa-carbidopa intestinal gel may prove more effective for long-term Parkinson treatment
Feb 27, 2015
After long-term treatment with oral medications for Parkinson disease, about most patients experience dyskinesias, end-of-dose wearing off, and fluctuations in "On/Off" states. Continuous dosing via a levodopa-carbidopa intestinal gel (LCIG) directly into the small intestine may be the key to reducing the motor complications associated with long-term levodopa use. In the current issue of the Journal of Parkinson's Disease, researchers report on the safety and efficacy of LCIG therapy over a 1-year period.
Could eating peppers prevent Parkinson disease?
May 09, 2013
New research reveals that Solanaceae—a flowering plant family with some species producing foods that are edible sources of nicotine—may provide a protective effect against Parkinson disease. The study appearing today in Annals of Neurology, suggests that eating foods that contain even a small amount of nicotine, such as peppers and tomatoes, may reduce risk of developing Parkinson disease.
Seeing a neurologist helps people with Parkinson disease live longer
Aug 11, 2011
People with Parkinson disease who go to a neurologist for their care are more likely to live longer, less likely to be placed in a nursing home, and less likely to break a hip than people who go to a primary care physician, according to a study published in the August 10, 2011, online issue of Neurology®, the medical journal of the American Academy of Neurology.
REM sleep behavior disorder is a risk factor for Parkinson disease
Jul 29, 2011
A new study used brain SPECT to conclude that the levels of dopamine in the brain are quickly lowering over the years in patients with REM sleep behavior disorder.
Scientist converts human skin cells into functional brain cells
Jul 28, 2011
A paper being published online today in the scientific journal Cell Stem Cell reveals efficient and robust methods for transforming adult skin cells into neurons that are capable of transmitting brain signals, marking one of the first documented experiments for transforming an adult human's skin cells into functioning brain cells.
Increased risk of Parkinson disease in methamphetamine users
Jul 26, 2011
People who abused methamphetamine or other amphetamine-like stimulants were more likely to develop Parkinson disease than those who did not, reports a new study from the Centre for Addiction and Mental Health.
New Parkinson disease gene identified
Jul 22, 2011
A team of researchers at the University Department of Neurology of the Medical University of Vienna has succeeded in identifying a gene that is mutated in individuals with Parkinson disease.
A mutation in a protein-sorting gene is linked with Parkinson disease
Jul 14, 2011
Two independent research groups have identified a mutation associated with an inherited form of Parkinson disease. The papers, published by Cell Press in the July 9 issue of The American Journal of Human Genetics, provide new insight into the pathogenesis of late-onset Parkinson disease and present compelling evidence that implicates a novel protein-recycling pathway in neurodegeneration.
Parkinson disease patients may benefit from virtual-reality-based therapies
Jul 12, 2011
In a study scheduled for publication in the August issue of the Archives of Physical Medicine and Rehabilitation, researchers report that virtual reality and physical reality exercises can be used to provide effective stimuli to increase movement speeds in Parkinson disease patients.
Ethnic and gender stereotypes bias treatment of Parkinson disease
Jul 07, 2011
Cultural, ethnic and gender stereotypes can significantly distort clinical judgments about "facially masked" patients with Parkinson disease, according to a newly published study. This can lead to inappropriate and inequitable health care for those suffering from Parkinson disease.
Getting an accurate read on Parkinson disease
Jun 30, 2011
Researchers have devised a unique algorithm to more precisely determine the size of a population that suffers from Parkinson disease. This will permit researchers to better prepare for the consequences to public health and provide more realistic estimates on how much it will cost to treat this growing number of patients.
New application for iPhone may support monitoring and research on Parkinson disease
Jun 24, 2011
Researchers at the Georgia Tech Research Institute have developed a novel iPhone application that may enable persons with Parkinson disease and certain other neurologic conditions to use the ubiquitous devices to collect data on hand and arm tremors and relay the results to medical personnel.
Lithium profoundly prevents brain damage associated with Parkinson disease
Jun 24, 2011
Lithium profoundly prevents the aggregation of toxic proteins and cell loss associated with Parkinson disease in a mouse model of the condition.
Discovery offers insights into link between Parkinson and pesticides
Jun 23, 2011
Researchers at the University of Missouri School of Medicine have taken some of the first steps toward unraveling the molecular dysfunction that occurs when proteins are exposed to environmental toxins. Their discovery helps further explain recent findings that demonstrate the link between Parkinson disease and 2 particular pesticides – rotenone and paraquat.
Rare genetic disorder provides unique insight into Parkinson disease
Jun 23, 2011
Massachusetts General Hospital investigators appear to have found the mechanism behind a previously reported link between the rare genetic condition Gaucher disease and the common neurodegenerative disorder Parkinson disease. In a report to appear in the July 8 issue of Cell they describe how disruption of the molecular pathway that causes Gaucher disease leads to the toxic neuronal deposits of the protein alpha-synuclein (a-syn) found in Parkinson disease and related disorders
Possible susceptibility genes found in progressive supranuclear palsy
Jun 20, 2011
An international research team has discovered 3 potential susceptibility genes for development of progressive supranuclear palsy, a rare neurodegenerative disease that causes symptoms similar to those of Parkinson disease but is resistant to Parkinson disease medications.
New clues about protein linked to Parkinson disease
Jun 17, 2011
Researchers at the Keck School of Medicine of the University of Southern California have uncovered structural clues about the protein linked to Parkinson disease, which ultimately could lead to finding a cure for the degenerative neurologic disorder.
Researchers identify why dopamine replacement therapy has a paradoxical effect on cognition
Jun 15, 2011
Canadian researchers have observed that while dopamine replacement therapy enhances the functions of the dorsal striatum, it is at the expense of the ventral striatum which suffers a dopamine overdose, impairing its function
Potential genetic cause of REM sleep behavior disorder discovered, Parkinson disease implications
Jun 15, 2011
Researchers at the University of Toronto are the first to identify a potential cause for a severe sleep disorder--REM sleep behavior disorder--that has been closely linked to Parkinson disease and other neurodegenerative diseases.
Copper folds protein into precursors of Parkinson disease plaques
Jun 14, 2011
Researchers have figured out how copper induces misfolding in the protein associated with Parkinson disease, leading to creation of the fibrillar plaques which characterize the disease. This finding has implications for both the study of Parkinson disease progression, as well as for future treatments.
New method for measuring Parkinson disease prevalence reveals sharp increase in Israel
Jun 10, 2011
In a new study published in the inaugural issue of the Journal of Parkinson's Disease, Israeli researchers report that by tracking pharmacy purchases of anti-Parkinson drugs they could estimate the number of Parkinson disease cases in a large population.
New animal study shows promise for development of Parkinson disease drug
Jun 09, 2011
In a new study published today in the inaugural issue issue of the Journal of Parkinson's Disease, an international group of researchers report that platelet-derived growth factor-BB (PDGF-BB) restored function in rodents and shows promise as a clinical candidate drug for treatment of Parkinson disease.
New genetic technique converts skin cells into brain cells
Jun 09, 2011
For the first time, a research group at Lund University in Sweden has succeeded in creating specific types of nerve cells from human skin. By reprogramming connective tissue cells, called fibroblasts, directly into nerve cells, a new field has been opened up with the potential to take research on cell transplants to the next level.
Connection discovered between the nervous system and the vascular system
Jun 08, 2011
Researchers have shown for the first time that a key molecule of the vascular system directs axons during the formation of neural circuits. This connection between the nervous system and the vascular system could be a good starting point for the development of therapies for neurodegenerative diseases.
People with Parkinson disease may have double the risk for melanoma
Jun 07, 2011
An analysis of several studies shows that people with Parkinson disease have a significantly higher risk of melanoma. The research is published in the June 7, 2011, print issue of Neurology®.
High risk of Parkinson disease for people exposed to pesticides near workplace
May 26, 2011
Researchers at UCLA are the first to implicate the pesticide ziram as a possible cause for Parkinson disease; their study results appear in the current online edition of the European Journal of Epidemiology.
Ulcer bacteria may contribute to development of Parkinson disease
May 23, 2011
The stomach bacteria responsible for ulcers could also play a role in the development of Parkinson disease according to research presented today at the 111th General Meeting of the American Society for Microbiology.
What doesn’t kill the brain makes it stronger
May 23, 2011
Johns Hopkins scientists say that a newly discovered "survival protein" protects the brain against the effects of stroke in rodent brain tissue by interfering with a particular kind of cell death that's also implicated in complications from diabetes and heart attack.
New understanding of brain chemistry could prevent brain damage after injury
May 16, 2011
A protective molecule--KCC2--has been identified in the brain which, if used artificially, may prevent brain damage from the likes of stroke, head injury, and Alzheimer disease.
Clinical Trials: Peripheral Neuropathy
Disruption of nerve cell supply chain may contribute to Parkinson disease
May 13, 2011
New data offer hints to why Parkinson disease so selectively harms brain cells that produce the chemical dopamine, say researchers at Washington University School of Medicine in St Louis.
Experts discover neurotransmitter with potential applications in treatment of neurologic disorders
May 06, 2011
A team of scientists has discovered that D-aspartic acid (D-Asp) is a novel neurotransmitter that could potentially be used in the fight against neurologic diseases such as Parkinson disease and schizophrenia. The research paper is published in the Journal of Federation of American Societies for Experimental Biology.
Researchers tracking down early diagnosis of Parkinson disease
Apr 29, 2011
In Parkinson disease, the human body generates antibodies to combat the amyloid-producing protein alpha synuclein early in the course of the disease. A simple blood test that measures these antibodies can facilitate early diagnosis of the disorder, according to a study published in the latest issue of the journal PLoS One.
The doctor will see all of you now? Group doctor visits may be feasible for Parkinson disease
Apr 28, 2011
Group appointments where doctors see several people for a longer time may be feasible for Parkinson disease, according to a new study published in the April 27, 2011, online issue of Neurology®, the medical journal of the American Academy of Neurology (AAN).
Low intensity treadmill exercise is best to improve walking in Parkinson disease
Apr 19, 2011
New evidence suggests that walking on a treadmill at a comfortable speed and for longer duration is the most effective exercise to improve mobility in people with Parkinson disease. That's according to the first randomized trial comparing 3 types of exercise training in Parkinson disease. The late-breaking research was presented at the 63rd Annual Meeting of the American Academy of Neurology, April 9-16, 2011, in Honolulu.
Investigational drug may reduce involuntary movements in people with Parkinson disease
Apr 18, 2011
Results of the first randomized, placebo-controlled, long-term clinical trial show the investigational drug safinamide may reduce dyskinesia, or involuntary movements, in mid-to-late stage Parkinson disease.
Healthy welders may be at increased risk for early brain damage
Apr 07, 2011
New research suggests that workers exposed to welding fumes may be at risk for developing brain damage in an area of the brain also affected in Parkinson disease. The study is published in the April 6, 2011, online issue of Neurology.
Skywalker ensures optimal communication between neurons
Apr 01, 2011
Researchers have now discovered an enzyme, christened Skywalker, that regulates the process in endosomes by which vesicle proteins are sorted to ensure optimal functioning of the recycled vesicles.
Promising clue to mechanism behind gene mutation that causes Parkinson disease
Mar 25, 2011
Researchers at Mount Sinai School of Medicine have discovered a way that mutations in a gene called LRRK2 may cause the most common inherited form of Parkinson disease.
First successful double-blind trial of gene therapy for advanced Parkinson disease
Mar 18, 2011
A multicenter gene therapy trial for patients with advanced Parkinson disease demonstrated reduced symptoms of the progressive movement disorder, according to a new study published in Lancet Neurology.
Vitamin D insufficiency high among patients with early Parkinson disease
Mar 16, 2011
Patients with a recent onset of Parkinson disease have a high prevalence of vitamin D insufficiency, but vitamin D concentrations do not appear to decline during the progression of the disease, according to a report in the March issue of Archives of Neurology.
Newly discovered role for enzyme in neurodegenerative diseases
Mar 11, 2011
Researchers find caspases prevent inflammation and thus constitute a potential target for drugs for neurodegenerative diseases such as Alzheimer and Parkinson disease.
Abnormal neural activity recorded from deep in the brain of Parkinson disease and dystonia patients
Mar 09, 2011
Researchers have successfully recorded cortically induced neural activity of basal ganglia in patients with Parkinson disease and dystonia during stereotaxic neurosurgery for deep brain stimulation.
Scientists create neurons with symptoms of Parkinson disease from patient’s skin cells
Mar 03, 2011
Neurons have been derived from the skin of a woman with a genetic form of Parkinson disease and have been shown to replicate some key features of the condition in a dish, say researchers at the Stanford University School of Medicine. The scientists hope to use the neurons to learn more about the disorder and to test possible treatments.
Research raises hope for solving Parkinson disease puzzle
Feb 28, 2011
A protein pathway that may hold the secret to understanding Parkinson disease has been discovered and explained by Iowa State University researchers.
Using amphetamines may increase risk of Parkinson disease
Feb 25, 2011
New research shows people who have used amphetamines such as benzedrine and dexedrine appear to be at an increased risk of developing Parkinson disease, according to a study released today that will be presented at the American Academy of Neurology’s 63rd Annual Meeting in Honolulu April 9 to April 16, 2011.
Study finds 2 pesticides associated with Parkinson disease
Feb 14, 2011
New research shows a link between use of 2 pesticides, rotenone and paraquat, and Parkinson disease. People who used either pesticide developed Parkinson disease approximately 2.5 times more often than nonusers.
Non-dopaminergic drug preladenant reduces motor fluctuations in patients with Parkinson disease
Feb 11, 2011
Preladenant, a non-dopaminergic medication, reduces off time in patients with Parkinson disease receiving standard dopamine therapy, an international study led by the University of South Florida found.
Research implicates natural toxin as Parkinson disease trigger
Feb 11, 2011
In new research from Saint Louis University, investigators have found evidence that a toxin produced by the brain is responsible for the series of cellular events that lead to Parkinson disease. The study, published in PLoS One, found that the brain toxin DOPAL plays a key role in killing the dopamine neurons which trigger the illness.
A possible cause of Parkinson disease discovered
Feb 01, 2011
The study finds defective nucleoli cause oxidative stress in cells, which can lead to massive cell damage and may be a key prerequisite for typical nerve damage of Parkinson disease.
Scientists shed light on what causes neuron death in Parkinson patients
Jan 07, 2011
This week in The Journal of Neuroscience, researchers demystified a process that leads to the death of neurons in Parkinson patients. When researchers blocked the process, the neurons survived.