High salt intake could be a risk factor for multiple sclerosis
Aug 05, 2015
Here's another reason to put the salt shaker down: new research in mice shows that diets high in sodium may be a novel risk factor in the development of multiple sclerosis by influencing immune cells that cause the disease. This finding was published in the August 2015 issue of The FASEB Journal.
Panel outlines new diagnostic criteria for neuromyelitis optica
Jul 09, 2015
New diagnostic criteria were introduced this week for neuromyelitis optica, now called neuromyelitis optica spectrum disorder (NMOSD)—an inflammatory disease of the CNS that is sometimes mistaken for multiple sclerosis. An international consensus panel reviewed the medical literature and recent scientific discoveries relating to NMOSD to develop new diagnostic criteria.
Study reveals brain network responsible for cognitive changes in multiple sclerosis
Jul 08, 2015
New findings published yesterday in Neuropsychology reveal that decreased connectivity between the dorsolateral prefrontal cortex and posterior brain regions are to blame for the central deficit common to the various cognitive changes associated with multiple sclerosis—slowed cognitive speed.
Discovery of a treatment to block the progression of multiple sclerosis
May 19, 2015
A drug that could halt the progression of multiple sclerosis may soon be developed thanks to a discovery by a team at the CHUM Research Centre and the University of Montreal. The researchers have identified a molecule called MCAM, and they have shown that blocking this molecule could delay the onset of the disease and significantly slow its progression. These encouraging results from in vitro tests in humans and in vivo tests in mice were published today in the Annals of Neurology.
Study implicates new gene in multiple sclerosis disease activity
May 15, 2015
A new study led by investigators at Brigham and Women's Hospital reports the discovery of a genetic variant that is associated with a patient's likelihood of responding to interferon-beta. Published in the Annals of Neurology on May 14, the study also presents evidence that the affected gene, SLC9A9, may have a broader role in regulating the development and activity of certain immune cells that play important roles in inflammatory diseases like multiple sclerosis.
Cytokine may play major role in multiple sclerosis
Apr 30, 2015
A study published online April 27th, in the Journal of Immunology, confirms that the cytokine GM-CSF (granulocyte macrophage colony-stimulating factor) likely plays an important role in human disease and offers a new explanation for why the multiple sclerosis treatment interferon-Beta (INF-ß) is often effective at reducing multiple sclerosis attacks.
Research identifies how vitamin D combats multiple sclerosis
Aug 16, 2011
A study published in the journal Molecular and Cellular Biology finds that vitamin D directly terminates the production of a disease-causing protein.
Researchers uncover genes linked to multiple sclerosis
Aug 10, 2011
An international team of scientists has identified 29 new genetic variants linked to multiple sclerosis, providing key insights into the biology of an important and very debilitating neurologic disease.
Newly discovered B cells suggest why women suffer more autoimmune disease
Aug 04, 2011
Researchers at National Jewish Health have discovered a type of cell that may contribute to autoimmune disease. The findings also suggest why diseases such as lupus, multiple sclerosis, and rheumatoid arthritis strike women more frequently than men.
Myelin influences how brain cells send signals
Jul 22, 2011
The development of a new cell-culture system that mimics how specific nerve cell fibers in the brain become coated with protective myelin opens up new avenues of research about multiple sclerosis. Initial findings suggest that myelin regulates a key protein involved in sending long-distance signals.
Multiple sclerosis drugs help, but come at high cost
Jul 21, 2011
A new study examining the cost-effectiveness of drugs to treat multiple sclerosis in the United States finds that the health gains from these drugs come at a very high cost compared to basic therapy to control the symptoms of multiple sclerosis and compared to treatments for other chronic diseases. The research is published in the July 20, 2011, online issue of Neurology.
Breastfeeding does not protect against multiple sclerosis relapses
Jul 07, 2011
New research finds breastfeeding doesn’t appear to protect against multiple sclerosis relapses, despite previous studies suggesting there may be a protective role.
Study finds pregnancy safe in multiple sclerosis
Jun 27, 2011
Canadian researchers have found that maternal multiple sclerosis is generally not associated with adverse delivery outcomes or risk to offspring.
Group therapy helps multiple sclerosis patients cope with depression
Jun 13, 2011
Researchers from the United Kingdom have found that multiple sclerosis sufferers who attended group therapy sessions had fewer problems with anxiety and depression, the impact of the disease on their daily lives was reduced, and their quality of life improved.
Study finds shingles may be related to elevated risk of multiple sclerosis
Jun 08, 2011
Taiwanese investigators have found that there can be a significantly higher risk of multiple sclerosis occurring in the year following a shingles, or herpes zoster, attack. The findings support a long-held view on how multiple sclerosis may develop, and are published in The Journal of Infectious Diseases.
Can stress increase the risk of multiple sclerosis?
May 31, 2011
Contrary to earlier reports, a new study finds that stress does not appear to increase a person's risk of developing multiple sclerosis. The research is published in the May 31, 2011, print issue of Neurology®.
Vitamin D levels low in African Americans with multiple sclerosis
May 24, 2011
African Americans who have multiple sclerosis have lower vitamin D levels than African Americans who don't have the disease, according to a study published in the May 24, 2011, print issue of Neurology®. However, most of the difference in vitamin D levels was due to differences in climate and geography.
New nanoscale imaging may lead to new treatments for multiple sclerosis
May 24, 2011
Laboratory studies by chemical engineers at UC Santa Barbara may lead to new experimental methods for early detection and diagnosis—and to possible treatments—for pathological tissues that are precursors to multiple sclerosis and similar diseases.
Viagra could reduce multiple sclerosis symptoms
May 19, 2011
Researchers have discovered that Viagra® drastically reduces multiple sclerosis symptoms in animal models with the disease. The research, published in Acta Neuropathologica, demonstrates that a practically complete recovery occurs in 50% of the animals after 8 days of treatment.
Epstein-Barr virus could be a risk factor for multiple sclerosis
May 17, 2011
The Epstein-Barr (EVB) virus—belonging to the herpesviruses family, which also includes the herpes simplex virus and the cytomegalovirus—is 1 of the environmental factors that might cause multiple sclerosis, confirmed University of Granada scientists.
New x-ray method for understanding brain disorders better
May 12, 2011
Researchers have developed a new method for making detailed x-ray images of brain cells. The method, called SAXS-CT, can map the myelin sheaths of neurons, which are important for conditions such as multiple sclerosis and Alzheimer disease.
Less than half of patients with multiple sclerosis continually adhere to treatment drug therapies
May 10, 2011
According to a new study led by St Michael's Hospital and the Institute for Clinical Evaluative Sciences, adherence to all disease-modifying drugs is low, with less than half of multiple sclerosis patients, or 44%, continually adherent after 2 years.
Reducing the side effects of a multiple sclerosis drug
May 09, 2011
A team of researchers has detailed the molecular mechanism by which FTY270 causes adverse effects in the lungs of mice. The findings suggest directions for the development of a safer drug.
Discovery demonstrates potential multiple sclerosis therapy could kill neurons
May 06, 2011
Researchers have discovered that some "protective" T-cells can kill neurons. This finding is significant because a specific type of T-cell therapy is being touted in the medical community as a potential treatment for multiple sclerosis and other autoimmune conditions.
GM-CSF required for the immune attack in multiple sclerosis
Apr 25, 2011
The neutralization of the cytokine GM-CSF could halt the development of multiple sclerosis. This was demonstrated by a research team at the University of Zurich in an animal model. Unlike other known cytokines, they write in the journal Nature Immunology, this messenger substance is essential for the development of the disease.
Oral drug for multiple sclerosis significantly reduces disease activity and slows disability
Apr 21, 2011
The drug laquinimod reduced the number of relapses for people with multiple sclerosis, in a large, long-term Phase 3 clinical study that was presented as late-breaking research at the 63rd Annual Meeting of the American Academy of Neurology, April 9-16, 2011, in Honolulu.
Common virus + low sunlight exposure may increase risk of multiple sclerosis
Apr 19, 2011
New research suggests that people who are exposed to low levels of sunlight coupled with a history of having the common virus mononucleosis may be at greater odds of developing multiple sclerosis than those without the virus. The research is published in the April 19, 2011, print issue of Neurology®, the medical journal of the American Academy of Neurology.
Marijuana use may hurt cognitive skills in multiple sclerosis patients
Mar 29, 2011
Any possible pain relief that marijuana has for people with multiple sclerosis may be outweighed by the drug's apparent negative effect on cognitive skills, according to research published in the March 29, 2011, print issue of Neurology.
Stem cells may show promise for people with rapidly progressing multiple sclerosis
Mar 22, 2011
A long-term study reports about the effectiveness of replacing bone marrow, purposely destroyed by chemotherapy, with autologous (self) stem cell rescue for people with aggressive forms of multiple sclerosis.
International panel revises ‘McDonald Criteria’ for diagnosing multiple sclerosis
Mar 10, 2011
An international panel has revised and simplified the "McDonald Criteria" commonly used to diagnose multiple sclerosis, incorporating new data that should speed the diagnosis without compromising accuracy.
Multiple sclerosis blocked in mouse model
Mar 08, 2011
Scientists have blocked harmful immune cells from entering the brain in mice with a condition similar to multiple sclerosis.
Psoriasis medication raises hope in the fight against multiple sclerosis
Mar 07, 2011
Neurologists report early online in the leading neurology journal Brain, that fumaric acid salts detoxify radicals released during the inflammation process. In this way, they protect nerve and glial cells.
Researchers publish results settling multiple sclerosis debate
Feb 24, 2011
For the first time researchers were able to definitively establish a cause-and-effect relationship linking marked T cells to the development of multiple sclerosis relapses and to show unambiguously that it was the same T cells that mediated relapsing cycles.
Warm weather may hurt cognitive skills in people with multiple sclerosis
Feb 18, 2011
People with multiple sclerosis may find it harder to learn, remember, or process information on warmer days of the year, according to new research released today that will be presented at the American Academy of Neurology's 63rd Annual Meeting in Honolulu April 9 to April 16, 2011.
More than allergies: histamine may be a possible drug target for multiple sclerosis
Feb 10, 2011
New research published in the Journal of Leukocyte Biology shows that histamine could be an important molecule to developing new treatments for multiple sclerosis.
Sun exposure, vitamin D may lower risk of multiple sclerosis
Feb 08, 2011
People who spend more time in the sun and those with higher vitamin D levels may be less likely to develop multiple sclerosis, according to a study published in the February 8, 2011, print issue of Neurology®.
Psoriasis medication raises hope in the fight against multiple sclerosis
Feb 07, 2011
Fumaric acid salts detoxify radicals released during the inflammation process, and in this way protect nerve and glial cells report neurologists in the early online edition of the journal Brain
AAN guideline: plasma exchange effective in treating multiple sclerosis relapses, neuropathies
Jan 18, 2011
A new guideline from the American Academy of Neurology recommends using plasma exchange to treat people with severe relapses in multiple sclerosis and related diseases, as well as those with certain kinds of neuropathies.
Women with multiple sclerosis more likely to have multiple sclerosis-related gene than men
Jan 06, 2011
Women who have multiple sclerosis are more likely to have a gene associated with multiple sclerosis than men with the disease and it is this gene region where environment interacts with the genetics, according to a study published in the January 5, 2011, online issue of Neurology®.
Link between cholesterol compound and multiple sclerosis unlikely, researchers say
Dec 15, 2010
New research findings indicate that compounds called oxysterols are not present in any significant amount in multiple sclerosis patients, contradicting a previous study that suggested that some of these cholesterol metabolites were associated with multiple sclerosis and could be used as diagnostic tools in the clinic.
Laboratory studies show promise for new multiple sclerosis treatment
Nov 19, 2010
A new study finds that a single injection of the compound ATL313—an anti-inflammatory drug being developed to treat chronic pain—stopped the progression of multiple sclerosis-caused paralysis in rats for weeks at a time.
Low vitamin D levels during pregnancy & breastfeeding may not be associated with multiple sclerosis
Nov 09, 2010
A small study suggests women with multiple sclerosis have lower vitamin D levels during pregnancy and breastfeeding, according to a report posted online today that will appear in the March 2011 print issue of Archives of Neurology. However, these vitamin D levels were not associated with a greater risk of multiple sclerosis relapse after childbirth.
Mindfulness meditation may ease fatigue, depression in multiple sclerosis
Sep 28, 2010
Learning mindfulness meditation may help people who have multiple sclerosis with the fatigue, depression, and other life challenges that commonly accompany the disease, according to a study published in the September 28, 2010, issue of Neurology®
FDA approves first oral drug to reduce multiple sclerosis relapses
Sep 24, 2010
The US Food and Drug Administration has approved Gilenya capsules (fingolimod) to reduce relapses and delay disability progression in patients with relapsing forms of multiple sclerosis.
New findings on multiple sclerosis—immune cells also attack neurons directly
Sep 23, 2010
Researchers in Germany have gained new insight into how the immune system causes damage associated with multiple sclerosis. Using imaging tools which enable investigation of processes in living organisms, they were able to show a direct interaction between immune cells and neurons which play a significant role in neuronal injury.
Asthma medication may benefit patients with multiple sclerosis
Sep 15, 2010
Adding albuterol, a compound commonly used to treat asthma and other respiratory diseases, to an existing treatment for patients with multiple sclerosis appears to improve clinical outcomes, according to a report in the September issue of Archives of Neurology.
Multiple sclerosis activity changes with the seasons
Aug 31, 2010
New research shows that the appearance of multiple sclerosis lesions on brain scans are 2 to 3 times higher in the summer months.
Gene variant may increase severity of multiple sclerosis
Aug 03, 2010
A new study finds that the oligoadenylate synthetase AA genotype increases the severity of multiple sclerosis symptoms.
New studies question vascular multiple sclerosis hypothesis and treatment
Aug 02, 2010
Two important new studies challenge the controversial hypothesis that venous congestion—chronic cerebrospinal venous insufficiency (CCSVI)—contributes to the development of multiple sclerosis (MS).
Brain atrophy responsible for depression in people battling multiple sclerosis
Jul 02, 2010
In the first such study in living humans, researchers at UCLA suggest a cause for depression in multiple sclerosis, and it's not psychological, but physical: atrophy of a specific region of the hippocampus.
Can mental activity protect against memory problems in multiple sclerosis?
Jun 16, 2010
A new study shows that a mentally active lifestyle may protect against the memory and learning problems that often occur in multiple sclerosis (MS).
Immune system helps transplanted stem cells navigate in CNS
Jun 02, 2010
By discovering how adult neural stem cells navigate to injury sites in the CNS, UC Irvine researchers have helped solve a puzzle in the creation of stem cell-based treatments: how do these cells know where to go?
Does smoking compound other multiple sclerosis risk factors?
Apr 18, 2010
A new study shows that smoking may increase the risk of multiple sclerosis (MS) in people who also have specific established risk factors for multiple sclerosis.
Researchers find further evidence linking Epstein-Barr virus and risk of multiple sclerosis
Mar 05, 2010
First long-term study among individuals not infected with Epstein-Barr virus suggests Epstein-Barr virus infection likely to be a cause of multiple sclerosis, not a consequence.
Exercise helps protect brain of multiple sclerosis patients
Feb 19, 2010
Highly fit multiple sclerosis patients perform significantly better on tests of cognitive function than similar less-fit patients, a new study shows. In addition, MRI scans of the patients showed that the fitter multiple sclerosis patients showed less damage in parts of the brain that show deterioration as a result of multiple sclerosis, as well as a greater volume of vital gray matter.
FDA approves Ampyra to improve walking in adults with multiple sclerosis
Jan 26, 2010
The US Food and Drug Administration has approved Ampyra (dalfampridine) extended release tablets to improve walking in patients with multiple sclerosis (MS). In clinical trials, patients treated with Ampyra had faster walking speeds than those treated with placebo. This is the first drug approved for this use.