Researchers discover role of microglia during early progression of Alzheimer disease
Oct 05, 2015
An experimental model of Alzheimer disease suggests microglia could facilitate the spread of tau fibrils between neurons by releasing tau-containing exosomes. This finding indicates that molecules involved in exosome release by microglia have a great potential as novel therapeutic targets to prevent the progression of the disease.
Old drug offers new hope to treat Alzheimer disease
Sep 21, 2015
Scientists from the Gladstone Institutes have discovered that salsalate, a drug used to treat rheumatoid arthritis, effectively reversed tau-related dysfunction in an animal model of frontotemporal dementia. Salsalate prevented the accumulation of tau in the brain and protected against cognitive impairments.
New, rapid dementia screening tool rivals ‘gold standard’ clinical evaluations
Aug 13, 2015
The Quick Dementia Rating System, which uses an evidence-based methodology, validly and reliably differentiates individuals with and without dementia. When dementia is present, it accurately stages the condition as very mild, mild, moderate, or severe. The test takes 3 to 5 minutes to complete, and can be used by a layperson.
Novel monoclonal antibodies show promise for Alzheimer disease treatment
Jul 20, 2015
Scientists at NYU Langone Medical Center's Center for Cognitive Neurology have evidence that monoclonal antibodies they developed may provide the blueprint for effective treatments for Alzheimer disease and other neurodegenerative diseases, such as Parkinson disease.
Alzheimer disease may affect the brain differently in African-Americans than European-Americans
Jul 16, 2015
Alzheimer disease may cause different pathologies in African-Americans than in white Americans of European descent, according to a new study by researchers in the Rush Alzheimer’s Disease Center at Rush University Medical Center. The study results appear in the July 15, 2015, issue of the medical journal of the American Academy of Neurology.
Diabetes complications linked to rising risk of dementia
Jul 13, 2015
People who have diabetes and experience high rates of complications are more likely to develop dementia as they age than people who have fewer diabetic complications, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
Scientists create mice with genetic cause of amyotrophic lateral sclerosis, frontotemporal dementia
May 22, 2015
Scientists at Mayo Clinic, Jacksonville, Florida created a novel mouse that exhibits the symptoms and neurodegeneration associated with the most common genetic forms of frontotemporal dementia and amyotrophic lateral sclerosis, both of which are caused by a mutation in the gene C9ORF72. The study was partially funded by the National Institutes of Health and published in the journal Science.
Brain imaging changes in individuals with Down symdrome, may help advance Alzheimer trials
Apr 14, 2015
Researchers have characterized 3 different brain imaging changes in individuals with Down syndrome even before the onset of progressive memory and thinking problems. Their findings could help set the stage to evaluate promising treatments to slow down or prevent the onset of Alzheimer symptoms in these individuals, according to a study published in Alzheimer's & Dementia.
Scientists use deep brain stimulation to treat dementia
Apr 06, 2015
Scientists from Nanyang Technological University, Singapore, have discovered that deep brain stimulation to the prefrontal cortex can be used to enhance the growth of neurons that mitigate the harmful effects of dementia-related conditions and improve short and long-term memory.
Characteristic pattern of protein deposits in brains of retired athletes who suffered concussions
Apr 06, 2015
A new UCLA study takes another step toward the early understanding of the degenerative brain condition chronic traumatic encephalopathy. Using a new imaging tool, researchers found a strikingly similar pattern of abnormal protein deposits in the brains of retired NFL players who suffered from concussions.
In Alzheimer disease mice, memory restored with cancer drug
Apr 01, 2015
The drug AZD05030 proved disappointing in treating solid cancer tumors but appears to block damage triggered during the formation of amyloid-beta plaques, a hallmark of Alzheimer disease. A new study has found that the drug restores synaptic connections and reduces inflammation in a mouse model.
Older adults with too much salt in diet and too little exercise at greater risk of cognitive decline
Aug 22, 2011
The finding, which appears online today in the journal Neurobiology of Aging, ahead of print publication, may have significant public health implications, emphasizing the importance of addressing multiple lifestyle factors that can impact brain health.
Can treatment with vitamin C dissolve amyloid plaques in Alzheimer disease?
Aug 18, 2011
Researchers at Lund University have discovered that treatment with vitamin C can dissolve the toxic protein aggregates that build up in the brain in Alzheimer disease. The research findings are now being presented in the Journal of Biological Chemistry.
Study identifies fish oil’s impact on cognition and brain structure
Aug 17, 2011
Researchers have found positive associations between fish oil supplements and cognitive functioning as well as differences in brain structure between users and non-users of fish oil supplements. The results were reported at the recent International Conference on Alzheimer's Disease, in Paris, France.
New treatment approach for Alzheimer disease
Aug 16, 2011
For the first time a research team succeeded in documenting how the immune system can counteract the advancement of Alzheimer disease.
Moderate drinking protects against Alzheimer disease and cognitive impairment
Aug 16, 2011
Moderate social drinking significantly reduces the risk of dementia and cognitive impairment, according to an analysis of 143 studies by Loyola University Chicago Stritch School of Medicine researchers.
Alzheimer disease symptoms more subtle in people over 80 years
Aug 12, 2011
A new study suggests that the relationship between brain shrinkage and memory loss in Alzheimer disease changes across the age spectrum. The research is published in the August 10, 2011, online issue of Neurology.
Sleep disordered breathing may increase risk of dementia in older women
Aug 10, 2011
Older women who have sleep-related breathing problems may be at greater risk of problems with mental function, including dementia, according to a new study in the August 10, 2011 issue of the Journal of the American Medical Association.
Common irregular heartbeat raises risk of dementia, including Alzheimer disease
Aug 08, 2011
The most common kind of chronically irregular heartbeat, known as atrial fibrillation, is associated with a greater risk of dementia, including Alzheimer disease. This discovery was published online in advance of print in the Journal of the American Geriatrics Society.
Researchers develop reliable, accurate blood test for Alzheimer disease
Aug 05, 2011
Scientists have developed a blood test that uses human protein microarrays to detect the presence of specific antibodies in the blood that can be used to diagnose Alzheimer disease with unprecedented accuracy.
Bypassing stem cells, scientists make neurons directly from human skin
Aug 04, 2011
Researchers have come up with a recipe for making functional neurons directly from human skin cells, including those taken from patients with Alzheimer disease. The new method may offer a critical short cut for generating neurons for replacement therapies of the future, according to research published in the August 5th issue of the journal Cell.
Subjective memory impairment as first sign of Alzheimer disease
Aug 03, 2011
German scientists have succeeded for the first time in demonstrating that even in merely subjective cases of memory deterioration changes may be visible in certain brain structures.
High blood pressure, diabetes, smoking, and obesity in middle age may shrink brain, damage thinking
Aug 02, 2011
A new study suggests smoking, high blood pressure, diabetes, and being overweight in middle age may cause brain shrinkage and lead to cognitive problems up to a decade later. The study is published in the August 2, 2011, print issue of Neurology®, the medical journal of the American Academy of Neurology.
Caregivers and their relatives disagree about care given, received
Aug 01, 2011
Caregivers and their relatives who suffer from mild to moderate dementia often have different perceptions regarding the amount and quality of care given and received. A study by researchers at Penn State and the Benjamin Rose Institute on Aging examined a major source of those differences—caregivers do not understand the things that are important to their relatives with dementia.
Hospice improves care for dementia patients and their families
Jul 29, 2011
Hospice services substantially improved the provision of care and support for nursing home patients dying of dementia and their families, according to an analysis of survey responses from hundreds of bereaved family members. The research comes as hospice funding has received particular scrutiny in the debate over Medicare spending.
Scientist converts human skin cells into functional brain cells
Jul 28, 2011
A paper being published online today in the scientific journal Cell Stem Cell reveals efficient and robust methods for transforming adult skin cells into neurons that are capable of transmitting brain signals, marking one of the first documented experiments for transforming an adult human's skin cells into functioning brain cells.
Exercise has numerous beneficial effects on brain health and cognition
Jul 25, 2011
In a new review article highlighting the results of more than a hundred recent human and animal studies on this topic, researchers show that both aerobic exercise and strength training play a vital role in maintaining brain and cognitive health throughout life. However, they also suggest that many unanswered questions remain in the field of exercise neuroscience—including how various aspects of exercise influence brain physiology and function and how human and animal studies relate to each other—and issue the call for further research to fill in these gaps.
International survey highlights great public desire to seek early diagnosis of Alzheimer disease
Jul 20, 2011
Results of an international survey reveal that over 85% of respondents in the 5 countries surveyed say that if they were exhibiting confusion and memory loss, they would want to see a doctor to determine if the cause of the symptoms was Alzheimer disease. Over 94% would want the same if a family member were exhibiting the symptoms. The findings were presented today at the Alzheimer's Association International Conference 2011.
Drug improves brain function in condition that leads to Alzheimer disease
Jul 20, 2011
An existing antiseizure drug improves memory and brain function in adults with a form of cognitive impairment that often leads to Alzheimer disease, a Johns Hopkins University study has found.
Falls may be early sign of Alzheimer disease
Jul 19, 2011
Falls and balance problems may be early indicators of Alzheimer disease, researchers at Washington University School of Medicine in St Louis report at the Alzheimer’s Association International Conference on Alzheimer’s Disease in Paris.
Over half of Alzheimer disease cases may be preventable
Jul 19, 2011
Over half of all Alzheimer disease cases could potentially be prevented through lifestyle changes and treatment or prevention of chronic medical conditions, according to a study at the San Francisco VA Medical Center.
Adult day care services provide much needed break to family caregivers, dementia patients also gain
Jul 18, 2011
Adult day care services significantly reduce the stress levels of family caregivers of older adults with dementia, and the dementia patients who attend adult day care centers have fewer behavior problems and sleep better at night, according to a team of Penn State and Virginia Tech researchers.
Researchers identify how a gene linked to both Alzheimer disease and type 2 diabetes works
Jul 18, 2011
Researchers at Mount Sinai School of Medicine have identified how a gene for a protein that can cause type 2 diabetes, also possibly kills nerve cells in the brain, thereby contributing to Alzheimer disease.
Molecules ‘light up’ Alzheimer roots
Jul 13, 2011
A breakthrough in sensing at Rice University could make finding signs of Alzheimer disease nearly as simple as switching on a light. The technique reported in the Journal of the American Chemical Society should help researchers design better medications to treat the devastating disease.
Overlooked peptide reveals clues to causes of Alzheimer disease
Jul 07, 2011
Researchers have shed light on the function of a little-studied amyloid peptide in promoting Alzheimer disease. Their surprising findings reveal that the peptide is more abundant, more neurotoxic, and exhibits a higher propensity to aggregate than amyloidogenic agents studied in earlier research, suggesting a potential role in new approaches for preventing Alzheimer disease-causing amyloidosis.
Overlooked peptide reveals clues to causes of Alzheimer disease
Jul 05, 2011
Researchers at the RIKEN Brain Science Institute and their collaborators have shed light on the function of a little-studied amyloid peptide in promoting Alzheimer disease. Their surprising findings reveal that the peptide is more abundant, more neurotoxic, and exhibits a higher propensity to aggregate than amyloidogenic agents studied in earlier research, suggesting a potential role in new approaches for preventing Alzheimer disease-causing amyloidosis.
New clues to the cause of Alzheimer disease
Jul 05, 2011
Researchers have identified a series of novel proteins in human cerebrospinal fluid. The proteins are found in greater concentrations in patients with dementia caused by Alzheimer disease than in patients with dementia caused by other diseases. This gives hope for new forms of treatment in the future.
Scientists uncover mechanism by which chronic stress causes brain disease
Jun 29, 2011
Chronic stress has long been linked with neurodegeneration. Scientists at USC now think they may know why. The study has tremendous implications for understanding and treating Alzheimer disease.
Study helps explain “sundowning” in elderly dementia patients
Jun 28, 2011
New research provides evidence that the late-day anxiety and agitation sometimes seen in older institutionalized adults, especially those with dementia, has a biological basis in the brain.
Mystery ingredient in coffee boosts protection against Alzheimer disease
Jun 22, 2011
A new Alzheimer mouse study by researchers at the University of South Florida has found that a yet unidentified component of coffee interacts with the beverage's caffeine to boost blood levels of a critical growth factor that seems to fight off the Alzheimer disease process.
Three postulates to help identify the cause of Alzheimer disease
Jun 21, 2011
To test the validity of present and future proposals related to the probable cause of Alzheimer disease, 3 postulates, or necessary conditions, are recommended in an article published in the Journal of Alzheimer’s Disease.
Natural Alzheimer disease weapon suggests better treatment
Jun 20, 2011
Scientists have shown a molecular chaperone is working like a waste management company to collect and detoxify high levels of toxic amyloid beta peptide found in Alzheimer disease.
Dietary changes appear to affect levels of biomarkers associated with Alzheimer disease
Jun 15, 2011
Following a low-saturated fat and low-glycemic index diet appears to modulate the risk of developing dementia that proceeds to Alzheimer disease (AD), although making a switch to this dietary pattern may not protect those already experiencing cognitive difficulty, according to a report in the June issue of Archives of Neurology.
Connection discovered between the nervous system and the vascular system
Jun 08, 2011
Researchers have shown for the first time that a key molecule of the vascular system directs axons during the formation of neural circuits. This connection between the nervous system and the vascular system could be a good starting point for the development of therapies for neurodegenerative diseases.
Scientists discover new direction in Alzheimer research
Jun 07, 2011
In what they are calling a new direction in the study of Alzheimer disease, UC Santa Barbara scientists have made an important finding about what happens to brain cells that are destroyed in Alzheimer disease and related dementias.
Study finds older adults with mild cognitive impairment may also have some functional impairment
Jun 07, 2011
Difficulty remembering important dates and medications, and gathering paperwork, is more common in older individuals with mild cognitive impairment than in those with no cognition problems, according to a report in the June issue of Archives of General Psychiatry.
Testosterone therapy improves memory in postmenopausal women
Jun 06, 2011
Postmenopausal women have better memory after daily treatment with a testosterone spray for 6 months, a new preliminary study finds. The results were presented at The Endocrine Society’s 93rd Annual Meeting in Boston.
Novel ‘prodrug’ alleviates symptoms in Huntington and Alzheimer mice
Jun 02, 2011
A study in a special early online publication of Cell reveals a promising new slow-release compound that protects mice against the neurodegenerative effects of both Huntington and Alzheimer disease. The 'prodrug' known only as JM6 works through a pathway involved in the breakdown of the amino acid tryptophan.
Difficulties in diagnosing dementia type
May 31, 2011
Many patients receive an incorrect dementia diagnosis according to a study carried out by neuropathology researchers in Lund, Sweden.
Potential new drug candidate found for Alzheimer disease
May 31, 2011
Researchers have demonstrated that oral administration of a cysteine protease inhibitor, E64d, not only reduces the build-up of beta-amyloid in the brains of animal models for Alzheimer disease, but also results in a substantial improvement in memory deficit.
Noncoding RNA may promote Alzheimer disease
May 30, 2011
Researchers pinpoint a small RNA that spurs cells to manufacture a particular splice variant of a key neuronal protein, potentially promoting Alzheimer disease or other types of neurodegeneration. The study appears in the May 30 issue of The Journal of Cell Biology.
Study identifies compounds that could slow down Alzheimer disease
May 26, 2011
A family of naturally occurring plant compounds could help prevent or delay memory loss associated with Alzheimer disease, according to a new study by the Translational Genomics Research Institute.
Researchers show reduced ability of the aging brain to respond to experience
May 25, 2011
Researchers at Mount Sinai School of Medicine have published new data on why the aging brain is less resilient and less capable of learning from life experiences. The findings provide further insight into the cognitive decline associated with aging and neurodegenerative diseases like Alzheimer disease.
New protein linked to Alzheimer disease
May 25, 2011
Scientists at The Feinstein Institute for Medical Research have discovered the molecule called c-Abl, which has a known role in leukemia, also has a hand in Alzheimer disease. The finding, reported in the June 14th issue of the Journal of Alzheimer's Disease, offers a new target for drug development that could stave off the pathological disease process.
Memory problems often not present in middle-aged people with Alzheimer disease
May 17, 2011
A new study suggests more than half of people who develop Alzheimer disease before the age of 60 are initially misdiagnosed as having other kinds of brain disease when they do not have memory problems. The research is published in the May 17, 2011, print issue of Neurology®.
New understanding of brain chemistry could prevent brain damage after injury
May 16, 2011
A protective molecule--KCC2--has been identified in the brain which, if used artificially, may prevent brain damage from the likes of stroke, head injury, and Alzheimer disease.
ACIP Recommendations (Advisory Committee for Immunization Practices)
Alzheimer disease risk gene disrupts brain’s wiring 50 years before disease hits
May 13, 2011
In the current online edition of the Journal of Neuroscience, UCLA researchers report that the C-allele of the CLU gene (an allele is 1 of 2 or more forms of a gene), which is possessed by 88% of Caucasians, impairs the development of myelin, the protective covering around the neuron's axons in the brain, making it weaker and more vulnerable to the onset of Alzheimer disease much later in life.
As time goes by, it gets tougher to ‘just remember this’
May 13, 2011
According to a Johns Hopkins neuroscientist aging brains are unable to process new information as "new" because the brain pathways leading to the hippocampus—the area of the brain that stores memories—become degraded over time. As a result, our brains cannot accurately "file" new information (like where we left the car that particular morning), and confusion results.
New x-ray method for understanding brain disorders better
May 12, 2011
Researchers have developed a new method for making detailed x-ray images of brain cells. The method, called SAXS-CT, can map the myelin sheaths of neurons, which are important for conditions such as multiple sclerosis and Alzheimer disease.
Evidence insufficient on the relationship of modifiable factors with the risk of Alzheimer disease
May 10, 2011
The available evidence is insufficient to draw firm conclusions about the association of modifiable factors and risk of Alzheimer disease, according to a report now posted online that will appear in the September issue of Archives of Neurology.
Dementia, mild cognitive impairment common in ‘oldest old’ women
May 10, 2011
Mild cognitive impairment, dementia, and their subtypes are common in the "oldest old" women, which includes those 85 years of age and older, according to a report in the May issue of Archives of Neurology.
Packing on the pounds in middle age linked to dementia
May 04, 2011
According to a new study, being overweight or obese during middle age may increase the risk of certain dementias. The research is published in the May 3, 2011, print issue of Neurology.
New route to map brain fat
May 04, 2011
Mapping the fat distribution of the healthy human brain is a key step in understanding neurologic diseases in general, and the neurodegeneration that accompanies Alzheimer disease in particular. Spanish researchers have found a new technique to reveal the fat distribution of 3 different areas of the healthy human brain. Their work is published online in the journal Analytical & Bioanalytical Chemistry.
Cells talk more in areas Alzheimer disease hits first, boosting plaque component
May 02, 2011
Higher levels of cell chatter boost amyloid beta in the brain regions that Alzheimer disease hits first, researchers at Washington University School of Medicine in St Louis report.
PET-CT exams help identify cognitive reserve in early-onset Alzheimer disease
May 02, 2011
A recent study revealed that the "cognitive reserve" in early-onset Alzheimer disease and PET-CT examinations can be used effectively to identify early-onset Alzheimer disease patients.
Higher levels of social activity decrease the risk of cognitive decline
Apr 26, 2011
According to research conducted at Rush University Medical Center, frequent social activity may help to prevent or delay cognitive decline in old age. The study has just been posted online in the Journal of the International Neuropsychological Society.
Alzheimer disease diagnostic guidelines updated for first time in decades
Apr 19, 2011
For the first time in 27 years, clinical diagnostic criteria for Alzheimer disease dementia have been revised, and research guidelines for earlier stages of the disease have been characterized to reflect a deeper understanding of the disorder.
Treating high blood pressure, cholesterol, diabetes may lower risk of Alzheimer disease
Apr 18, 2011
Treating high blood pressure, high cholesterol, diabetes, and other vascular risk factors may help lower the risk of Alzheimer disease in people who already show signs of declining thinking skills or memory problems. The research is published in the April 13, 2011, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Brain starts shrinking nearly a decade before Alzheimer disease appears
Apr 14, 2011
Areas of the brain affected by Alzheimer disease may start shrinking up to a decade before dementia is diagnosed, according to a new study published in the April 13, 2011, issue of Neurology®, the medical journal of the American Academy of Neurology.
Evidence lacking for efficacy of memantine in treating mild Alzheimer disease
Apr 11, 2011
An analysis of studies involving the drug memantine finds a lack of evidence for benefit when the drug is used to treat patients with mild Alzheimer disease, according to a report posted online today that will appear in the August print issue of Archives of Neurology.
MRI may contribute to early detection of Alzheimer disease
Apr 11, 2011
New research suggests that magnetic resonance imaging (MRI) could help detect Alzheimer disease at an early stage, before irreversible damage has occurred, according to a new study published online and in the June print edition of Radiology.
Blood biomarker associated with prevalence, severity of Alzheimer disease
Apr 06, 2011
Higher levels in blood of the protein clusterin, also known as apolipoprotein J, are significantly associated with the prevalence and severity of Alzheimer disease (AD), but not with the risk of onset of new disease, according to a study in the April 6 issue of JAMA.
Researchers link herpes to Alzheimer disease
Apr 04, 2011
Researchers have developed a new technique to observe herpes simplex virus type 1 (HSV1) infections growing inside cells. HSV1, the cause of the common cold sore, persists in a latent form inside nerve cells. They have found that reactivation and growth of HSV1 infections contribute to cognitive decline associated with Alzheimer disease. Details are published in the March 31 issue of PLoS ONE magazine from the Public Library of Science.
Alzheimer-like brain changes found in cognitively normal elders with amyloid plaques
Mar 30, 2011
Researchers using 2 brain-imaging technologies have found that apparently normal older individuals with brain deposits of amyloid beta – the primary constituent of the plaques found in the brains of Alzheimer disease patients – also had changes in brain structure similar to those seen in Alzheimer patients.
Scientists ID possible biomarker to gauge Alzheimer prognosis, effect of therapies
Mar 18, 2011
UCLA researchers have identified a new biomarker that could help them track how effectively the immune system is able to clear the brain of amyloid beta, which forms the plaques considered one of the hallmarks of Alzheimer disease.
Newly discovered role for enzyme in neurodegenerative diseases
Mar 11, 2011
Researchers find caspases prevent inflammation and thus constitute a potential target for drugs for neurodegenerative diseases such as Alzheimer and Parkinson disease.
More evidence that Alzheimer disease may be inherited from your mother
Mar 01, 2011
Study finds people with a mother who had Alzheimer disease had twice as much gray matter shrinkage as people who had a father or no parent with Alzheimer disease.
Alzheimer disease may be easily misdiagnosed
Feb 25, 2011
New research shows that Alzheimer disease and other dementing illnesses may be easily misdiagnosed in the elderly, according to early results of a study of people in Hawaii who had their brains autopsied after death.
Hearing loss associated with development of dementia
Feb 17, 2011
Older adults with hearing loss appear more likely to develop dementia, and their risk increases as hearing loss becomes more severe, according to a report in the February issue of Archives of Neurology.
Tau-induced memory loss in Alzheimer mice is reversible
Feb 16, 2011
A study in mice shows that the progression of Alzheimer disease can be reversed in principle—at least at an early stage of the illness before too many neurons have been destroyed.
Good diets fight bad Alzheimer genes
Feb 15, 2011
In preliminary results, researchers are exhilarated to find that a diet high in Omega 3 oils and low in cholesterol appears to significantly reduce the negative effects of the APOE4 gene in mouse models.
Chemists make discovery that may lead to drug treatment possibilities for Alzheimer disease
Feb 11, 2011
UC Santa Barbara scientists have made a discovery that has the potential for use in the early diagnosis and eventual treatment of plaque-related diseases such as Alzheimer disease and Type 2 diabetes.
Imaging procedure can identify biomarker associated with Alzheimer disease
Jan 21, 2011
Preliminary research suggests that use of a type of molecular imaging procedure may have the ability to detect the presence of beta-amyloid in the brains of individuals during life, according to a study in the January 19 issue of JAMA.