Study reveals effects of chemoradiation in brains of glioblastoma patients
Aug 18, 2015
A new study - the first to examine the effects of combined radiation and chemotherapy on the healthy brain tissue of glioblastoma patients - reveals not only specific structural changes within patients' brains, but also that the effect of cancer therapy on the normal brain appears to be progressive and continues even after radiation therapy has ceased.
Targeted therapy shows effectiveness against a subtype of medulloblastoma
Jul 30, 2015
Vismodegib, a targeted therapy already used to treat advanced skin cancer, is also effective against the most common subtype of the brain tumor medulloblastoma in adults and should be considered for treatment of newly diagnosed patients, according to research led by St Jude Children’s Research Hospital.
Nanotechnology identifies brain tumor types through MRI ‘virtual biopsy’ in animal studies
May 25, 2015
Biomedical researchers at Cedars-Sinai have invented a tiny drug-delivery system that can identify cancer cell types in the brain through "virtual biopsies" and then attack the molecular structure of the disease. If laboratory research with mice is borne out in human studies, results could be used to deliver nano-scale drugs that can distinguish and fight tumor cells in the brain without resorting to surgery.
Anti-CD47 treatment shows promise in fight against glioblastoma multiforme
May 04, 2015
Results of a new study indicate that in vitro disruption of the CD47-SIRPa signal induced a response from both M1 and M2 macrophages; however, the rate and responsiveness of phagocytosis by M1 macrophages was consistently greater. In addition, phenotypic evaluation of local macrophages surrounding transplanted GBM tissue in mice suggests that anti-CD47 treatment promotes a larger local M1 population.
Scientists observe deadly dance between nerves and cancer cells
Apr 29, 2015
Study findings appearing in Nature Communications challenge conventional wisdom about perineural invasion, which holds that cancer cells are marauders that invade nerves through the path of least resistance. This study instead discovered that perineural invasion is actually a much more intricately choreographed biochemical give-and-take between the nerves and the cancer cells.
New brain tumor gene identified for meningiomas
Aug 08, 2011
The causes of brain tumors have been hard to discern in most cases. But an international collaboration of researchers have discovered a genetic variation--a gene variant that is close to MLLT10 on chromosome 10--that increases the risk of meningiomas.
Scientists map genes for oligodendroglioma
Aug 05, 2011
Johns Hopkins Kimmel Cancer Center scientists have completed a comprehensive map of genetic mutations occurring in the second-most common form of brain cancer, oligodendroglioma. The findings, reported in the August 4 issue of Science, also appear to reveal the biological cause of the tumors.
Stem cells restore cognitive abilities impaired by brain cancer treatment
Jul 13, 2011
Human neural stem cells are capable of helping people regain learning and memory abilities lost due to radiation treatment for brain tumors, a UC Irvine study suggests.
Indirubin—component of Chinese herbal remedy—might block brain tumor spread
Jul 12, 2011
Ohio State University researchers have discovered that the compound indirubin both blocks the migration of glioblastoma cells, preventing their spread to other areas of the brain, and the migration of endothelial cells, preventing them from forming the new blood vessels that the tumor needs to grow.
Exercise associated with longer survival after brain cancer diagnosis
Jun 21, 2011
Brain cancer patients who are able to exercise live significantly longer than sedentary patients, scientists at the Duke Cancer Institute report.
Vaccine study supports immune targeting of brain tumors
Jun 16, 2011
An experimental vaccine developed by researchers at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute targets overactive antigens in highly aggressive brain tumors and improves length of survival in newly diagnosed patients, according to new data that was presented in a poster session at the 47th Annual Meeting of the American Society of Clinical Oncology.
Study finds vaccine extends recurrent gliobastoma survival rates by 2 to 3 times
Jun 03, 2011
In data presented at The American Society of Clinical Oncology Annual Meeting, cancer researchers found that the brain tumor vaccine HSPPC-96 for treating recurrent gliobastoma has a favorable safety profile and extends survival by 2 to 3 times more than the current median survival rate.
Iron key to brain tumor drug delivery
Jun 02, 2011
Brain cancer therapy may be more effective if the expression of an iron-storing protein is decreased to enhance the action of therapeutic drugs on brain cancer cells, according to Penn State College of Medicine researchers.
Minimizing side effects from chemoradiation could help brain cancer patients live longer
Apr 19, 2011
Minimizing neurologic side effects in patients with high-grade glioma from chemoradiation may result in improved patient survival, a new study from radiation oncologists at the Kimmel Cancer Center at Jefferson suggests.
FDA approves new medical device for form of brain cancer
Apr 15, 2011
The US Food and Drug Administration recently approved the NovoTTF-100A System, a new device to treat adults with glioblastoma multiforme that recurs or progresses after receiving chemotherapy and radiation therapy.
Scientists find potential benefit of hypericin for recurrent brain tumors
Apr 08, 2011
Researchers have found that a synthetic version of hypericin, a compound naturally found in St John's wort, may be a promising treatment for patients with recurrent malignant brain tumors. Their findings were published online on March 31, 2011 in the journal Cancer.
Epileptic seizures linked to significant risk of subsequent brain tumor
Apr 06, 2011
Epileptic seizures can precede the development of a subsequent brain tumor by many years, suggests research published online in the Journal of Neurology, Neurosurgery and Psychiatry.
Research targets way to stop brain tumor cell invasion
Mar 29, 2011
A study finds that the drug Icatibant, which is already in use in Europe, and its ability to block B2R receptors may prove to be a very promising target for further investigation for the treatment of malignant gliomas.