Childhood epilepsy not linked with later psychiatric disorders
Sep 21, 2015
A study of young adults has found no substantial or lasting association between childhood epilepsy and psychiatric disorders and suicidal behavior.
Seizures in neonates undergoing cardiac surgery underappreciated and dangerous
Aug 20, 2015
A new study that placed 161 neonates who had undergone cardiac surgery on continuous EEG monitoring found that 8% of the neonates experienced EEG seizures and 85% of these were unrecognized clinically. Many of the seizures were severe, and the seizure group faced a higher risk of death, according to a report in The Journal of Thoracic and Cardiovascular Surgery.
Quiet that ringing in the brain
Jun 23, 2015
A new drug may treat epilepsy and prevent tinnitus by selectively affecting potassium channels in the brain, UConn researchers report in the Journal of Neuroscience.
Recommendations address how to manage seizures in infants
Jun 01, 2015
In an Epilepsia report, child neurologists note that intervening at the time of a febrile seizure does not alter the risk for subsequent epilepsy, and there is no evidence to support the use of antiepileptic drugs for simple febrile seizures. However, recurrent seizures warrant an urgent assessment, and a variety of antiepileptic drugs may benefit these patients.
Single, low-magnitude electric pulse vagus nerve stimulation successfully fights inflammation
May 13, 2015
In a paper published by Bioelectronic Medicine, researchers explore how low-level electrical stimulation interacts with the body's nerves to reduce inflammation. The paper's findings indicate that activation of either motor or sensory vagus nerve bundles can diminish inflammation.
Study finds new genetic clues to developmental epilepsies
Apr 03, 2015
Researchers have identified a new genetic mutation--salt-inducible kinase 1(SIK1)--associated with developmental epilepsies. The finding, which was reported yesterday in the journal American Journal of Human Genetics, may help scientists unravel the complex biological mechanism behind these diseases.
Researchers identify possible trigger point of epileptic seizures
Aug 22, 2011
Researchers at the Stanford University School of Medicine have identified a brain-circuit defect that triggers absence seizures, the most common form of childhood epilepsy.
A better approach to diagnosing and treating epilepsy
Aug 01, 2011
Using state-of-the-art, 7 Tesla magnetic resonance imaging (MRI) technology, University of Minnesota Medical School researchers may have uncovered a better approach to diagnosing epilepsy. In the process, the team was able to cure 8 patients of all epileptic symptoms.
Fast ripples confirmed to be valuable biomarker of area responsible for seizure activity in children
Jul 29, 2011
New research focusing on high-frequency oscillations, termed ripples and fast ripples, recorded by intracranial electroencephalography (EEG), may provide an important marker for the localization of the brain region responsible for seizure activity, according to a study now available in Epilepsia.
A gene discovery in truffle dogs sheds new light on the mechanisms of childhood epilepsy
Jul 28, 2011
The gene discovery made by a research group at the University of Helsinki and the Folkhälsan Rsearch Center offers a new candidate gene for human benign childhood epilepsies characterized by seizure remission.
Study highlights success of brain surgery for severe epilepsy
Jul 21, 2011
Two thirds of people with severe and otherwise untreatable epilepsy were completely cured of their frequent seizures after undergoing neurosurgery at the University of California, San Francisco Medical Center, according to a new study that examined 143 of these patients 2 years after their operations.
Greater seizure frequency seen in women with epilepsy during anovulatory cycle
Jul 14, 2011
A recent multicenter study determined that women with generalized tonic-clonic seizures had a greater number of seizures during anovulatory cycles—menstrual cycles where an egg is not released—than in cycles where ovulation occurs. According to the study publishing today in Epilepsia, reproductive steroids may play a role ingeneralized tonic-clonic seizure occurrence.
Variation in make-up of generic epilepsy drugs can lead to dosing problems
Jul 05, 2011
Generic anti-epilepsy drugs, pharmaceutical products similar to brand-name versions, save consumers billions of dollars each year, but some are different enough from branded formulations that they may not be effective, particularly if patients switch between two generic drugs.
Researchers find master switch for adult epilepsy
Jun 27, 2011
UC Irvine and French researchers have identified a central switch responsible for the transformation of healthy brain cells into epileptic ones, opening the way to both treat and prevent temporal lobe epilepsy.
Understanding the antiepileptic benefits of an Atkins-like diet
Jun 23, 2011
Some individuals with epilepsy fail to respond to treatment with conventional drugs but benefit from consuming a ketogenic diet—a high-fat, low-carbohydrate diet similar to the more commonly known Atkins diet. A team of researchers has now identified in mice the molecular mechanism responsible for the antiepileptic effects of the ketogenic diet.
Neuroscientists’ discovery could bring relief to epilepsy sufferers
Jun 21, 2011
Researchers at the University of California, Riverside have made a discovery in the lab that could help drug manufacturers develop new antiepileptic drugs and explore novel strategies for treating seizures associated with epilepsy.
Research reveals effectiveness of seizure treatments for children with autism
Jun 03, 2011
Physicians will have a better guide for more effectively managing treatment of children experiencing seizures related to autism with the results of a study by researchers at Arizona State University and the University of Texas-Houston.
Cognitive impairment seen in preschool children with epilepsy
Jun 02, 2011
A recent study has shown that cognitive impairment is evident early on in preschool children with epilepsy, consistent with results of similar studies in older children. Age of onset of first seizure is a significant predictor of cognitive impairment according to this study—the first to evaluate cognitive impairment in children age 3 to 6.
Prenatal use of newer antiepileptic drugs not associated with increased risk of major birth defects
May 17, 2011
Use of newer-generation antiepileptic drugs during the first trimester of pregnancy was not associated with an increased risk of major birth defects in the first year of life among infants in Denmark, according to a study in the May 18 issue of JAMA.
New understanding of brain chemistry could prevent brain damage after injury
May 16, 2011
A protective molecule--KCC2--has been identified in the brain which, if used artificially, may prevent brain damage from the likes of stroke, head injury, and Alzheimer disease.
New direction for epilepsy treatment
Apr 28, 2011
Researchers from Italy found that giving mice repeated doses of a specific enzyme inhibitor significantly reduced both chronic epileptic activity and acute seizures. Their findings, published online in the journal Neurotherapeutics, open up the possibility of a new target system for anticonvulsant drug intervention, to control epileptic activity that does not respond to certain anticonvulsant treatments.
Medication non-adherence among children with epilepsy associated with socioeconomic status
Apr 27, 2011
An examination of medication adherence among children with newly diagnosed epilepsy found that nearly 60% showed persistent nonadherence during the first 6 months of therapy, and that lower socioeconomic status was associated with higher non-adherence, according to a study in the April 27 issue of JAMA.
New drug may reduce seizures in epilepsy
Apr 20, 2011
A new drug called perampanel appears to significantly reduce seizures in people with hard-to-control epilepsy, according to results of the first clinical trial to test the higher 12 mg dose of the drug. The late-breaking research was presented at the 63rd Annual Meeting of the American Academy of Neurology, April 9-16, 2011, in Honolulu.
Mortality rate is increased in persons with autism who also have epilepsy
Apr 15, 2011
A comprehensive investigation of brain tissue donated to the Autism Speaks Autism Tissue Program (ATP), a postmortem brain tissue donation program, determined that one third of the brain donors with autism also had epilepsy, and co-morbidity data from the California State Department of Developmental Services revealed a higher than expected rate of mortality in individuals with both autism and epilepsy than for individuals with autism alone.
A world first: the discovery of a common genetic cause of autism and epilepsy
Apr 08, 2011
Researchers from the Centre hospitalier de l'Université de Montréal Research Centre have identified a new gene--synapsin gene (SYN1)-- that predisposes people to both autism and epilepsy.
Epileptic seizures linked to significant risk of subsequent brain tumor
Apr 06, 2011
Epileptic seizures can precede the development of a subsequent brain tumor by many years, suggests research published online in the Journal of Neurology, Neurosurgery and Psychiatry.
Potassium channel gene modifies risk for epilepsy
Apr 04, 2011
Vanderbilt University researchers have identified a new gene that can influence a person's risk for developing epilepsy. The findings, reported in the March 29 Proceedings of the National Academy of Sciences, could improve molecular diagnostic tools and point to novel therapeutic targets for epilepsy.
Higher prevalence of psychiatric symptoms found in children with epilepsy
Mar 25, 2011
A newly published report reveals that children with epilepsy are more likely to have psychiatric symptoms, with gender a determining factor in their development. Findings showed that girls had more emotional problems, while boys had more hyperactivity/inattention problems and issues regarding peer relationships.