The drug laquinimod reduced the number of relapses for people with multiple sclerosis (MS), in a large, long-term Phase 3 clinical study that was presented as late-breaking research at the 63rd Annual Meeting of the American Academy of Neurology, April 9-16, 2011, in Honolulu.
The study involved 1106 people with relapsing-remitting multiple sclerosis in 24 countries. The participants received either a once daily oral dose of 0.6 mg of laquinimod or a matching placebo for 2 years. Eighty percent of those taking laquinimod and 77% of those taking the placebo finished the 2-year study.
Patients treated with laquinimod experienced a statistically significant reduction of 23% in annual relapse rate, compared to patients treated with a placebo. Additionally, there was a reduction of 36% in disability progression, as well as a 33% reduction in brain atrophy for those people treated with laquinimod.
"These exciting results confirm that laquinimod has a significant impact on progression of disability and disease activity, while maintaining a high safety profile," said lead author Giancarlo Comi MD, director of the Department of Neurology and Institute of Experimental Neurology at the Scientific Institute and University Vita-Salute San Raffaele in Milan, Italy. "This may be attributed to the novel mechanism of action of laquinimod, which effectively and safely addressed both the acute inflammatory activity and the accumulation of irreversible tissue damage. This suggests a substantial future role for laquinimod in the treatment of MS."
Laquinimod was safe and well tolerated. Overall frequencies of adverse events were low and comparable to those observed in the placebo group. "The incidence of liver enzyme elevation was higher in laquinimod treated patients," said Comi. "However, these elevations were temporary, reversible and did not lead to any signs of liver problems."
The study was supported by Teva Pharmaceuticals.
Source: News Release
American Academy of Neurology
April 14, 2011