Gene variant may increase severity of multiple sclerosis

Aug 03, 2010

A new study shows a gene variant may increase the severity of multiple sclerosis (MS) symptoms. The research will be published in the August 3, 2010, issue of Neurology®, the medical journal of the American Academy of Neurology.

For the study, researchers screened the oligoadenylate synthetase (OAS1) gene in 401 people with multiple sclerosis, 394 people without multiple sclerosis, and 178 people receiving the multiple sclerosis treatment beta interferon.

On the analysis of the OAS1 gene, 63% of people with multiple sclerosis had the AA genotype compared to 57% of people without multiple sclerosis. The GG genotype was found in 37% of people with multiple sclerosis compared to 43% of people without the disease.

While the OAS1 gene was weakly associated with disease susceptibility, the study found that people who had the AA genotype had earlier relapses and increased disease activity compared to those without the genotype.

"While we don't understand why some patients vary so widely in their disease activity, this genetic association may give us clues to help direct future research," said study author Margaret O'Brien PhD, with St Vincent's University Hospital in Dublin, Ireland.

The study also found people who had the GG genotype had less disease activity and fewer relapses. "It's possible that the GG genotype may protect against increased disease activity in people with MS, but more research is needed," said O'Brien.

The study was supported by Science Foundation Ireland, the Health Research Board of Ireland, and MS Ireland.

Source: News Release
American Academy of Neurology
August 2, 2010