A 5-minute checklist that parents can fill out in pediatrician waiting rooms may someday help in the early diagnosis of autism spectrum disorder (ASD), according to a study funded by the National Institutes of Health. Published today in the Journal of Pediatrics, the study's design also provides a model for developing a network of pediatricians to adopt such a change to their practice.
"Beyond this exciting proof of concept, such a screening program would answer parents' concerns about their child's possible ASD symptoms earlier and with more confidence than has ever been done before," noted Thomas R Insel MD, director of the National Institute of Mental Health (NIMH), part of NIH.
Identifying autism at an early age allows children to start treatment sooner, which can greatly improve their later development and learning. However, many studies show a significant delay between the time parents first report concerns about their child's behavior and the eventual autism spectrum disorder diagnosis, with some children not receiving a diagnosis until well after they've started school.
Recognizing the need to improve early autism spectrum disorder screening, Karen Pierce PhD, of the University of California, San Diego, and colleagues established a network of 137 pediatricians across San Diego County. Following an hour-long educational seminar, the pediatricians screened all infants at their 1-year, well-baby check-up using the Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist, a brief questionnaire that detects autism spectrum disorder, language delay, and developmental delay. The questionnaire asks caregivers about a child's use of eye gaze, sounds, words, gestures, objects, and other forms of age-appropriate communication. Any child who failed the screen was referred for further testing and was re-evaluated every 6 months until age 3 years.
Out of 10,479 infants screened, 32 were identified as having autism spectrum disorder. After excluding for late onset and regression cases, this is consistent with current rates that would be expected at 12 months, according to the researchers. When including those identified as having language delay, developmental delay, or some other form of delay, the brief screen provided an accurate diagnosis 75% of the time.
Following the screen, all toddlers diagnosed with autism spectrum disorder or developmental delay and 89% of those with language delay were referred for behavioral therapy. On average, these children were referred for treatment around age 17 months. For comparison, a 2009 study using data from the Centers for Disease Control and Prevention found that, on average, children currently receive an autism spectrum disorder diagnosis around 5.7 years (68.4 months) of age, with treatment beginning sometime later.
In addition to tracking infant outcomes, the researchers also surveyed the participating pediatricians. Prior to the study, few of the doctors had been screening infants systematically for autism spectrum disorder. After the study, 96% of the pediatricians rated the program positively, and 100% of the practices have continued using the screening tool.
"In the context of a virtual lack of universal screening at 12 months, this program is one that could be adopted by any pediatric office, at virtually no cost, and can aid in the identification of children with true developmental delays," said Dr Pierce.
The researchers note that future studies should seek to further validate and refine this screening tool, track children until a much older age, and assess barriers to treatment follow up.
This study was also supported by an NIMH Autism Center of Excellence grant as well as Autism Speaks and the Organization for Autism Research.
Source: News Release
NIH/National Institute of Mental Health
April 28, 2011