Neuropathy Center

Neuropathies are disorders that affect one or more peripheral nerves causing weakness, clumsiness and disturbances of sensation and coordination. They include mononeuropathies, polyneuropathies, peripheral neuropathies, mononeuritis multiplex, sensory neuropathies, motor neuropathies, and sensorimotor neuropathies.

Overview Articles

Acute autonomic neuropathies
Chemotherapy-induced neuropathies
Clinical evaluation of peripheral neuropathies
Drug-induced neurologic disorders
Drug-induced neuropathies
Idiopathic sensory and sensorimotor neuropathies
Mitochondrial disorders
Neuromuscular pathology: overview
Nutrition-related peripheral neuropathies
Small fiber neuropathies
Toxic peripheral neuropathies
Vasculitic neuropathies

Specific Non-Hereditary Neuropathies

Acute inflammatory demyelinating polyradiculoneuropathy
(Guillain-Barre syndrome)
Arsenic neuropathy
Bell palsy
Brachial neuritis
Carpal tunnel syndrome
Complex regional pain syndrome
(Causalgia; reflex sympathetic dystrophy)
Critical illness myopathy and polyneuropathy
Diabetic neuropathies
Lead neuropathy
Mercury neuropathy
Motor and multifocal motor neuropathies
Paraneoplastic sensory neuronopathy
Peroneal neuropathy
Radial neuropathy
(Saturday night palsy)
Radiation plexopathy
Sciatic neuropathy
Ulnar neuropathy at the elbow
Uremic neuropathy

Hereditary Polyneuropathies

The following disorders may be early manifestations of multiple sclerosis or may never progress beyond their initial manifestations.
Adrenoleukodystrophy
Charcot-Marie-Tooth disease type 1A
Choreoacanthocytosis
Hereditary motor and sensory neuropathy 1A
Hereditary neuropathy with predisposition to pressure palsy
Metachromatic leukodystrophy and related disorders
Neuroacanthocytosis

Related Articles

Contributing causes of distal sensory neuropathy in diabetic patients
CSF antibodies versus a CSF antibody index to diagnose Lyme neuroborreliosis?
How useful is sural nerve biopsy and what are the complications?
Neurologic complications of cocaine, amphetamine, and their derivatives

Treatment Information

Autonomic neuropathy: treatment
Evaluation and management of orthostatic hypotension
Immunotherapy in neuromuscular disorders
Neuropathic pain: treatment
Peripheral neuropathies: treatment with neurotrophic factors
Rehabilitation of peripheral nerve diseases
Treatment of nervous system Lyme disease

External Resources

AAN Guideline: Botulinum Neurotoxin in the Treatment of Autonomic Disorders and Pain
AAN Guidelines: Neuromuscular Disorders
Clinical Trials: Peripheral Neuropathy
Clinical Trials: Small Fiber Neuropathy
NGC Guideline: Carpal Tunnel Syndrome
NGC Treatment Guideline: Complex Regional Pain Syndrome (3rd Edition)
NINDS Guillain-Barre Syndrome Information Page
Video: Sensory Assessment - Discriminatory Sensations
Video: Sensory Assessment - Vibration and Position

Communities

Neuropathy Community Forum
Support for patients with peripheral neuropathy and related neurological disorders. Discussions among patients, families, caregivers and professionals on topics related to diagnosis, treatment, and activities of daily living.

News

Neuropathy patients more likely to receive high-cost screening instead of more effective tests
Jan 24, 2012
Almost one quarter of patients receiving neuropathy diagnoses undergo high-cost, low-yield MRIs, whereas very few receive low-cost, high-yield glucose tolerance tests, according to a study published in the Archives of Internal Medicine.
Omega-3 fatty acids could prevent and treat nerve damage
Jan 11, 2012
Research from Queen Mary, University of London suggests that omega-3 fatty acids, which are found in fish oil, have the potential to protect nerves from injury and help them to regenerate.
Possible therapy for an inherited neuropathy
Nov 02, 2011
Work in mice, by a team of researchers at Massachusetts General Hospital and Harvard Medical School, has revealed a rational candidate oral therapy for 1 hereditary neuropathy -- hereditary sensory and autonomic neuropathy type 1 (HSAN1).
Popular colorectal cancer drug may cause permanent nerve damage
Sep 28, 2011
Oxaliplatin, a platinum-based anticancer drug that's made enormous headway in recent years against colorectal cancer, appears to cause nerve damage that may be permanent and worsens even months after treatment ends.
New imaging technique evaluates nerve damage
Sep 13, 2011
A new imaging technique could help doctors and researchers more accurately assess the extent of nerve damage and healing in a live patient, report researchers at Laval University in Québec and Harvard Medical School in Boston.
Mice point to a therapy for Charcot-Marie-Tooth disease
Aug 02, 2011
VIB researchers have developed a mouse model for Charcot-Marie-Tooth neuropathy. They also found a potential therapy for this incurable disease. The treatment not only halted the damage to the nerves and the atrophy of the muscles, it even succeeded in reversing the symptoms.
Diabetes drug may help prevent neuropathic pain
Jul 26, 2011
The diabetes drug rosiglitazone (Avandia) can control inflammation leading to nerve damage and abnormal pain responses, suggests a paper in the August issue of Anesthesia & Analgesia.
Breathing restored after spinal cord injury in rodent model
Jul 13, 2011
Researchers at Case Western Reserve University School of Medicine bridged a spinal cord injury and biologically regenerated lost nerve connections to the diaphragm, restoring breathing in an adult rodent model of spinal cord injury. The work, which restored 80% to more than 100% of breathing function, will be published in the online issue of the journal Nature July 14.
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