Multiple Sclerosis Center

Multiple sclerosis is a highly variable disorder that usually presents with recurrent, painless episodes of neurologic symptoms at 15 to 50 years of age.

Comprehensive Article

Multiple sclerosis
This comprehensive clinical reference includes information on many different areas of MS, including:

Key Articles

Autoantibodies
Fatigue in multiple sclerosis
Immunomodulatory agents in multiple sclerosis: clinical trials and therapy
Multiple sclerosis: biological differences in children and adults
Multiple sclerosis: neurobehavioral aspects
Multiple sclerosis: treatment of its symptoms
Natalizumab and PML in MS
Sleep and multiple sclerosis
Spasticity

Early Manifestations of Multiple Sclerosis

The following disorders may be early manifestations of multiple sclerosis or may never progress beyond their initial manifestations.
Acute disseminated encephalomyelitis
Balo concentric sclerosis
Clinically isolated syndrome
Optic neuritis
Transverse myelitis

Unusual Manifestations of Multiple Sclerosis

Pain, headache, and oromandibular structures
Tumefactive multiple sclerosis

Disorders Sometimes Confused with MS

The manifestations of multiple sclerosis are very variable. There are therefore many other disorders that can be misdiagnosed as multiple sclerosis. The greatest impostor is neuromyelitis optica.
Adrenoleukodystrophy
Alexander disease
CADASIL
Childhood ataxia with central nervous system hypomyelination
Hemiplegic migraine
Hereditary spastic paraplegia
HTLV-1 associated myelopathy
Subcortical vascular cognitive impairment
The white matter lesions seen in this disorder may be cited in MRI reports as evidence for multiple sclerosis.
Susac syndrome

Treatment Information

Azathioprine
Dalfampridine
Fingolimod
Glatiramer acetate
Interferon beta 1a
Interferon beta 1b
Intrathecal baclofen
Mitoxantrone
Mycophenolate
Natalizumab
Tizanidine

External Resources

AAN Guideline: Neutralizing Antibodies to Interferon-beta: Clinical and Radiographic Impact
AAN Guidelines: Multiple Sclerosis
EFNS Guidelines On the Use of Neuroimaging In the Management Of Multiple Sclerosis
FDA Advisory: Natalizumab - Update of Healthcare Professional Information
MS Society of Canada
MS Society of Great Britain and Northern Ireland
Multiple Sclerosis Association of America
Multiple Sclerosis International Federation
National MS Society: Professional Resource Center
NICE Guideline: Management of Multiple Sclerosis in Primary and Secondary Care
Video: Multiple sclerosis - histopathology spinal cord
Video: Neuromyelitis optica
Video: Patient Guide to Managing MS

Communities

Multiple Sclerosis Community Forum
Support for patients with multiple sclerosis and related neurological disorders. Discussions among patients, families, caregivers and professionals on topics related to diagnosis, treatment, and activities of daily living.

News

Discovery of a treatment to block the progression of multiple sclerosis
May 19, 2015
A drug that could halt the progression of multiple sclerosis may soon be developed thanks to a discovery by a team at the CHUM Research Centre and the University of Montreal. The researchers have identified a molecule called MCAM, and they have shown that blocking this molecule could delay the onset of the disease and significantly slow its progression. These encouraging results from in vitro tests in humans and in vivo tests in mice were published today in the Annals of Neurology.
Study implicates new gene in multiple sclerosis disease activity
May 15, 2015
A new study led by investigators at Brigham and Women's Hospital reports the discovery of a genetic variant that is associated with a patient's likelihood of responding to interferon-beta. Published in the Annals of Neurology on May 14, the study also presents evidence that the affected gene, SLC9A9, may have a broader role in regulating the development and activity of certain immune cells that play important roles in inflammatory diseases like multiple sclerosis.
Cytokine may play major role in multiple sclerosis
Apr 30, 2015
A study published online April 27th, in the Journal of Immunology, confirms that the cytokine GM-CSF (granulocyte macrophage colony-stimulating factor) likely plays an important role in human disease and offers a new explanation for why the multiple sclerosis treatment interferon-Beta (INF-ß) is often effective at reducing multiple sclerosis attacks.
New anti-inflammatory molecule could halt multiple sclerosis progression
Mar 16, 2015
Scientists have developed a new drug-like molecule that can halt inflammation and has shown promise in preventing the progression of multiple sclerosis. The small drug-like molecule is called WEHI-345. It binds to and inhibits a key immune signaling protein called RIPK2, which prevents the release of inflammatory cytokines.
A real eye-opener: narcolepsy bears classic autoimmune hallmarks
Mar 09, 2015
A new study published in Pharmacological Research finds that narcolepsy bears the trademarks of a classic autoimmune disorder and should be treated accordingly. The research points to a particular autoimmune process as the trigger for the specific loss of orexin neurons, which maintain the delicate equilibrium between sleep and wakefulness in the brain
Stem cell transplantation shows potential for reducing disability in multiple sclerosis patients
Jan 20, 2015
Results from a preliminary study indicate that among patients with relapsing-remitting multiple sclerosis, treatment with nonmyeloablative hematopoietic stem cell transplantation (low intensity stem cell transplantation) was associated with improvement in measures of disability and quality of life, according to a study in the January 20 issue of JAMA.
Researchers identify chemical compound that decreases effects of multiple sclerosis
Dec 02, 2014
A team of researchers reports in this week's issue of the Proceedings of the National Academy of Sciences that when indazole chloride is administered on transgenic mice, it can potentially halt the symptoms of MS and reverse ongoing motor deficit. In addition, the study shows that indazole chloride can remyelinate axons which have gotten injured.
Study blocks multiple sclerosis relapses in mice
Nov 12, 2014
In a new study, researchers from the University of Pennsylvania and co-investigators have identified a key protein that is able to reduce the severity of a disease equivalent to multiple sclerosis in mice. This molecule, Del-1, is the same regulatory protein that has been found to prevent inflammation and bone loss in a mouse model of gum disease.
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