Multiple sclerosis is a highly variable disorder that usually presents with recurrent, painless episodes of neurologic symptoms at 15 to 50 years of age.
Multiple Sclerosis Community Forum
Support for patients with multiple sclerosis and related neurological disorders. Discussions among patients, families, caregivers and professionals on topics related to diagnosis, treatment, and activities of daily living.
New anti-inflammatory molecule could halt multiple sclerosis progression
Mar 16, 2015
Scientists have developed a new drug-like molecule that can halt inflammation and has shown promise in preventing the progression of multiple sclerosis. The small drug-like molecule is called WEHI-345. It binds to and inhibits a key immune signaling protein called RIPK2, which prevents the release of inflammatory cytokines.
A real eye-opener: narcolepsy bears classic autoimmune hallmarks
Mar 09, 2015
A new study published in Pharmacological Research finds that narcolepsy bears the trademarks of a classic autoimmune disorder and should be treated accordingly. The research points to a particular autoimmune process as the trigger for the specific loss of orexin neurons, which maintain the delicate equilibrium between sleep and wakefulness in the brain
Stem cell transplantation shows potential for reducing disability in multiple sclerosis patients
Jan 20, 2015
Results from a preliminary study indicate that among patients with relapsing-remitting multiple sclerosis, treatment with nonmyeloablative hematopoietic stem cell transplantation (low intensity stem cell transplantation) was associated with improvement in measures of disability and quality of life, according to a study in the January 20 issue of JAMA.
Researchers identify chemical compound that decreases effects of multiple sclerosis
Dec 02, 2014
A team of researchers reports in this week's issue of the Proceedings of the National Academy of Sciences that when indazole chloride is administered on transgenic mice, it can potentially halt the symptoms of MS and reverse ongoing motor deficit. In addition, the study shows that indazole chloride can remyelinate axons which have gotten injured.
Study blocks multiple sclerosis relapses in mice
Nov 12, 2014
In a new study, researchers from the University of Pennsylvania and co-investigators have identified a key protein that is able to reduce the severity of a disease equivalent to multiple sclerosis in mice. This molecule, Del-1, is the same regulatory protein that has been found to prevent inflammation and bone loss in a mouse model of gum disease.
Intestinal barrier damage in multiple sclerosis
Sep 04, 2014
A new study investigates whether the function of the intestines is attacked in multiple sclerosis. The results, obtained from a disease model of multiple sclerosis in mice, shows inflammation and changes in the barrier function of the intestines early in the course of the disease. The study has been published in the scientific journal PLOS ONE.
Researchers publish first study of brain activation in multiple sclerosis using fNIRS
Aug 28, 2014
Using functional near infrared spectroscopy (fNIRS), Kessler Foundation researchers have shown differential brain activation patterns between people with multiple sclerosis and healthy controls. This is the first multiple sclerosis study in which brain activation was studied using fNIRS while participants performed a cognitive task. The article was published online in Brain Imaging and Behavior.
Scientists one step closer to cell therapy for multiple sclerosis patients
Jul 25, 2014
For the first time, scientists generated induced pluripotent stem cells lines from skin samples of patients with primary progressive multiple sclerosis and further, they developed an accelerated protocol to induce these stem cells into becoming oligodendrocytes, the myelin-forming cells of the central nervous system implicated in multiple sclerosis and many other diseases.