Multiple sclerosis is a highly variable disorder that usually presents with recurrent, painless episodes of neurologic symptoms at 15 to 50 years of age.
Multiple Sclerosis Community Forum
Support for patients with multiple sclerosis and related neurological disorders. Discussions among patients, families, caregivers and professionals on topics related to diagnosis, treatment, and activities of daily living.
Molecular sensor detects early signs of multiple sclerosis
Dec 04, 2013
Scientists at the Gladstone Institutes have devised a new molecular sensor that can detect multiple sclerosis at its earliest stages—even before the onset of physical signs. In a new study the scientists reveaedl in animal models that the heightened activity of the protein thrombin in the brain could serve as an early indicator of multiple sclerosis.
New imaging research shows increased iron in the brain in earliest stages of multiple sclerosis
Oct 29, 2013
New imaging research from Western University (London, Canada) found iron deposits in deep gray matter, suggesting the accumulation occurs very early in the disease course. The researchers also found evidence casting further doubt on the controversial liberation therapy for multiple sclerosis. The research is in early publication online in Multiple Sclerosis and Related Disorders.
New strategy to treat multiple sclerosis shows promise in mice
Oct 10, 2013
Scientists have identified a set of compounds that may be used to treat multiple sclerosis in a new way. One of the newly identified compounds, a Parkinson disease drug called benztropine, was highly effective in treating a standard model of multiple sclerosis in mice, both alone and in combination with existing multiple sclerosis therapies.
Sending multiple sclerosis up in smoke
Oct 08, 2013
In a new study published in the Journal of Neuroimmune Pharmacology, researchers demonstrate that some chemical compounds found in marijuana can help treat multiple sclerosis-like diseases in mice by preventing inflammation in the brain and spinal cord.
Breakthrough offers first direct measurement of spinal cord myelin in multiple sclerosis
Sep 23, 2013
Case Western Reserve University School of Medicine scientists have developed a novel molecular probe detectable by PET imaging. The new molecular marker, MeDAS, offers the first noninvasive visualization of myelin integrity of the entire spinal cord at the same time, as published today in an article in the Annals of Neurology.
Regional gray matter atrophy in multiple sclerosis causes neuropsychological problems
Aug 09, 2013
Researchers suggest that gray matter atrophy exists in relapsing-remitting multiple sclerosis, and the cingulate and frontal cortices of the dominant hemisphere are the most severely atrophic regions of the brain. Additionally, this atrophy is correlated with cognitive decline and emotional abnormalities. These findings are published in the Neural Regeneration Research.
Scientists decode mechanisms of cell orientation in the brain
Jul 31, 2013
When the central nervous system is injured, oligodendrocyte precursor cells migrate to the lesion and synthesize new myelin sheaths on demyelinated axons. Scientists have now discovered that a distinct protein regulates the direction and movement of oligodendrocyte precursor cells toward the wound. The transmembrane protein NG2, which is expressed at the surface of oligodendrocyte precursor cells and down-regulated as they mature to myelinating oligodendrocytes, plays an important role in the reaction of oligodendrocyte precursor cells to wounding.
Multiple sclerosis research could help repair damage affecting nerves
Jul 22, 2013
A study by the Universities of Edinburgh and Cambridge found that immune cells, known as macrophages, help trigger the regeneration of myelin. Researchers found that following loss of or damage to myelin, macrophages can release a compound called activin-A, which activates production of more myelin.