Multiple Sclerosis Center

Multiple sclerosis is a highly variable disorder that usually presents with recurrent, painless episodes of neurologic symptoms at 15 to 50 years of age.

Comprehensive Article

Multiple sclerosis
This comprehensive clinical reference includes information on many different areas of MS, including:

Key Articles

Fatigue in multiple sclerosis
Immunomodulatory agents in multiple sclerosis: clinical trials and therapy
Multiple sclerosis: neurobehavioral aspects
Multiple sclerosis: treatment of its symptoms
Natalizumab and PML in MS
Sleep and multiple sclerosis

Early Manifestations of Multiple Sclerosis

The following disorders may be early manifestations of multiple sclerosis or may never progress beyond their initial manifestations.
Acute disseminated encephalomyelitis
Balo concentric sclerosis
Clinically isolated syndrome
Optic neuritis
Transverse myelitis

Unusual Manifestations of Multiple Sclerosis

Pain, headache, and oromandibular structures
Tumefactive multiple sclerosis

Disorders Sometimes Confused with MS

The manifestations of multiple sclerosis are very variable. There are therefore many other disorders that can be misdiagnosed as multiple sclerosis. The greatest impostor is neuromyelitis optica.
Alexander disease
Childhood ataxia with central nervous system hypomyelination
Hemiplegic migraine
Hereditary spastic paraplegia
HTLV-1 associated myelopathy
Neuromyelitis optica
(Devic disease)
Subcortical vascular cognitive impairment
The white matter lesions seen in this disorder may be cited in MRI reports as evidence for multiple sclerosis.
Susac syndrome

Treatment Information

Glatiramer acetate
Interferon beta 1a
Interferon beta 1b
Intrathecal baclofen

External Resources

AAN Guideline: Neutralizing Antibodies to Interferon-beta: Clinical and Radiographic Impact
AAN Guidelines: Multiple Sclerosis
EFNS Guidelines On the Use of Neuroimaging In the Management Of Multiple Sclerosis
FDA Advisory: Natalizumab - Update of Healthcare Professional Information
MS Society of Canada
MS Society of Great Britain and Northern Ireland
Multiple Sclerosis Association of America
Multiple Sclerosis International Federation
National MS Society: Professional Resource Center
NICE Guideline: Management of Multiple Sclerosis in Primary and Secondary Care
Video: Multiple sclerosis - histopathology spinal cord
Video: Neuromyelitis optica
Video: Patient Guide to Managing MS


Multiple Sclerosis Community Forum
Support for patients with multiple sclerosis and related neurological disorders. Discussions among patients, families, caregivers and professionals on topics related to diagnosis, treatment, and activities of daily living.


Growth factor in stem cells may spur recovery from multiple sclerosis
May 21, 2012
A substance in human mesenchymal stem cells that promotes growth appears to spur restoration of nerves and their function in rodent models of multiple sclerosis, researchers at Case Western Reserve University School of Medicine have found.
Latest multiple sclerosis research results
May 16, 2012
There were over 500 scientific presentations and display posters focused on research to stop multiple sclerosis at the American Academy of Neurology's annual meeting. Among these were the latest results from pviotal clinical trials of emerging MS therapies, possible risk factors, underlying disease mechanisms, rehabilitation approaches, CCSVI, and much more.
Smoked cannabis reduces some symptoms of multiple sclerosis
May 15, 2012
A clinical study of 30 adult patients with multiple sclerosis at the University of California, San Diego School of Medicine has shown that smoked cannabis may be an effective treatment for spasticity – a common and disabling symptom of this neurologic disease.
Study shows halting an enzyme can slow multiple sclerosis in mice
Apr 30, 2012
In a study published this month in Brain Pathology, a group at Mayo Clinic finds that an antibody that neutralizes Kallikrein 6 is capable of staving off multiple sclerosis in mice.
‘Significant’ symptom relief in multiple sclerosis patients with angioplasy
Mar 26, 2012
Researchers who investigated the connection between chronic cerebrospinal venous insufficiency and multiple sclerosis indicate that a minimally invasive endovascular treatment is safe and may produce "significant," short-term improvement in physical- and mental health-related quality of life in individuals with multiple sclerosis.
Interventional radiology: mitigating symptoms of multiple sclerosis patients
Mar 26, 2012
Researchers report that performing angioplasty on veins in the neck and chest is safe—and may be an effective way to treat the venous abnormalities found in those with multiple sclerosis and provide symptom relief.
Lifestyle study highlights key differences in relapsing and progressive onset multiple sclerosis
Mar 19, 2012
Patients with relapsing onset multiple sclerosis who consumed alcohol, wine, coffee, and fish on a regular basis took 4 to 7 years longer to reach the point where they needed a walking aid than people who never consumed them. However the study did not observe the same patterns in patients with progressive onset multiple sclerosis.
Study documents negative effect of warmer weather on cognitive performance in multiple sclerosis
Mar 14, 2012
Kessler Foundation scientists have shown for the first time that outdoor temperature significantly affects cognitive functioning in multiple sclerosis. Although it is recognized that disease activity increases during warmer months, this is the first study to document that cognition also fluctuates.
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