Alzheimer disease is the most common dementia, characterized by intellectual deterioration, usually beginning with memory loss and mild cognitive impairment (MCI). Dementia is sometimes inappropriately referred to as senility and wrongly attributed to arteriosclerosis (hardening of the arteries). Alzheimer disease is also written as Alzheimer's disease and Alzheimers disease.
Alzheimers Community Forum
Support for patients with Alzheimer disease, memory loss, mild cognitive impairment (MCI), dementia, and related neurological disorders. Discussions among patients, families, caregivers and professionals on topics related to diagnosis, treatment, and activities of daily living.
Researchers discover role of microglia during early progression of Alzheimer disease
Oct 05, 2015
An experimental model of Alzheimer disease suggests microglia could facilitate the spread of tau fibrils between neurons by releasing tau-containing exosomes. This finding indicates that molecules involved in exosome release by microglia have a great potential as novel therapeutic targets to prevent the progression of the disease.
Old drug offers new hope to treat Alzheimer disease
Sep 21, 2015
Scientists from the Gladstone Institutes have discovered that salsalate, a drug used to treat rheumatoid arthritis, effectively reversed tau-related dysfunction in an animal model of frontotemporal dementia. Salsalate prevented the accumulation of tau in the brain and protected against cognitive impairments.
New, rapid dementia screening tool rivals ‘gold standard’ clinical evaluations
Aug 13, 2015
The Quick Dementia Rating System, which uses an evidence-based methodology, validly and reliably differentiates individuals with and without dementia. When dementia is present, it accurately stages the condition as very mild, mild, moderate, or severe. The test takes 3 to 5 minutes to complete, and can be used by a layperson.
Novel monoclonal antibodies show promise for Alzheimer disease treatment
Jul 20, 2015
Scientists at NYU Langone Medical Center's Center for Cognitive Neurology have evidence that monoclonal antibodies they developed may provide the blueprint for effective treatments for Alzheimer disease and other neurodegenerative diseases, such as Parkinson disease.
Alzheimer disease may affect the brain differently in African-Americans than European-Americans
Jul 16, 2015
Alzheimer disease may cause different pathologies in African-Americans than in white Americans of European descent, according to a new study by researchers in the Rush Alzheimer’s Disease Center at Rush University Medical Center. The study results appear in the July 15, 2015, issue of the medical journal of the American Academy of Neurology.
Diabetes complications linked to rising risk of dementia
Jul 13, 2015
People who have diabetes and experience high rates of complications are more likely to develop dementia as they age than people who have fewer diabetic complications, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
Scientists create mice with genetic cause of amyotrophic lateral sclerosis, frontotemporal dementia
May 22, 2015
Scientists at Mayo Clinic, Jacksonville, Florida created a novel mouse that exhibits the symptoms and neurodegeneration associated with the most common genetic forms of frontotemporal dementia and amyotrophic lateral sclerosis, both of which are caused by a mutation in the gene C9ORF72. The study was partially funded by the National Institutes of Health and published in the journal Science.
Brain imaging changes in individuals with Down symdrome, may help advance Alzheimer trials
Apr 14, 2015
Researchers have characterized 3 different brain imaging changes in individuals with Down syndrome even before the onset of progressive memory and thinking problems. Their findings could help set the stage to evaluate promising treatments to slow down or prevent the onset of Alzheimer symptoms in these individuals, according to a study published in Alzheimer's & Dementia.