ALS and Other Motor Neuron Disorders Center

Amyotrophic lateral sclerosis (ALS) and other motor neuron disorders are characterized by selective degeneration of motor nerve cells and their fibers, producing progressive paralysis.


ALS Community Forum
Support for patients with ALS and similar neurological disorders. Discussions among patients, families, caregivers and professionals on topics related to diagnosis, treatment, and activities of daily living.


Effect of presymptomatic BMI, dietary intake, alcohol on amyotrophic lateral sclerosis
Aug 17, 2015
Presymptomatic patients with the neurodegenerative disease amyotrophic lateral sclerosis (ALS) consumed more daily calories but had lower body-mass index than those individuals without ALS in a study in the Netherlands that also looked at risk for the disease and associations with food and alcohol intake, according to an article published online by JAMA Neurology.
Uncovering key relationship in amyotrophic lateral sclerosis
Jul 15, 2015
A University of Toronto research team has discovered new details about a key gene--C9orf72--involved in amyotrophic lateral sclersosis (ALS). The possible involvement of C9orf72 in the shuttling between nucleus and cytoplasm opens intriguing new avenues of research into the causes of ALS and hopefully one day an effective treatment or cure.
New treatment hope for amyotrophic lateral sclerosis
Jun 15, 2015
A previously unknown link between the immune system and the death of motor neurons in amyotrophic lateral sclerosis has been discovered by scientists at the CHUM Research Centre and the University of Montreal. The study, published in Nature Communications, shows that the immune system in the animal model C. elegans plays a critical role in the development of amyotrophic lateral sclerosis.
Research points to future test for amyotrophic lateral sclerosis
Jun 04, 2015
Researchers at the University of Toronto have uncovered new insights on the genetic causes of amyotrophic lateral sclerosis. These findings could uncover a new way to detect a genetic predisposition to amyotrophic lateral sclerosis before the disease strikes.
Scientists create mice with genetic cause of amyotrophic lateral sclerosis, frontotemporal dementia
May 22, 2015
Scientists at Mayo Clinic, Jacksonville, Florida created a novel mouse that exhibits the symptoms and neurodegeneration associated with the most common genetic forms of frontotemporal dementia and amyotrophic lateral sclerosis, both of which are caused by a mutation in the gene C9ORF72. The study was partially funded by the National Institutes of Health and published in the journal Science.
Researchers find new link between neurodegenerative diseases and abnormal immune responses
Mar 30, 2015
A study published today in Nature Immunology, offers new insight into the link between neurodegenerative disorders and inflammation, and provides a framework to explore more fully the possibility that viral infection may lead to onset of these diseases.
Scientists identify mutation in SIGMAR1 gene linked to juvenile amyotrophic lateral sclerosis
Aug 12, 2011
Researchers from the Kingdom of Saudi Arabia have identified a mutation on the SIGMAR1 gene associated with the development of juvenile amyotrophic lateral sclerosis. Study findings published today in Annals of Neurology show the gene variant affects Sigma-1 receptors which are involved in motor neuron function and disease development.
New model of amyotrophic lateral sclerosis is based on human cells from autopsied tissue
Aug 11, 2011
By isolating cells from patients' spinal tissue within a few days after death, researchers have developed a new model of amyotrophic lateral sclerosis. They found that during the disease, cells called astrocytes become toxic to nerve cells – a result previously found in animal models but not in humans.
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