ALS and Other Motor Neuron Disorders Center

Amyotrophic lateral sclerosis (ALS) and other motor neuron disorders are characterized by selective degeneration of motor nerve cells and their fibers, producing progressive paralysis.


ALS Community Forum
Support for patients with ALS and similar neurological disorders. Discussions among patients, families, caregivers and professionals on topics related to diagnosis, treatment, and activities of daily living.


Disease progression halted in rat model of amyotrophic lateral sclerosis
Dec 12, 2011
Researchers now show that progressive neuron degeneration can be halted in a rat model of familial amyotrophic lateral sclerosis linked to mutations in the gene that carries the instructions for making the protein TDP-43.
The implications of disease coexistence
Nov 29, 2011
A study published in the Journal of Molecular Neuroscience, in a special issue entitled Frontotemporal Dementias, highlights the importance of diagnosing 'overlap syndrome' in sufferers of amyotrophic lateral sclerosis and frontotemporal dementia.
New amyotrophic lateral sclerosis drug slows symptom progression, reduces mortality in phase 2 trial
Nov 21, 2011
Treatment with dexpramipexole – a novel drug believed to prevent dysfunction of mitochondria, the subcellular structures that provide most of a cell's energy – appears to slow symptom progression in amyotrophic lateral sclerosis. Promising results of a phase 2 trial of dexpramipexole are receiving advance online publication in Nature Medicine.
Genetic screening in yeast reveals new candidate gene for amyotrophic lateral sclerosis
Nov 15, 2011
Mutations in 2 related proteins, TDP-43 and FUS, cause some forms of amyotrophic lateral sclerosis. In a new study, researchers at the Perelman School of Medicine at the University of Pennsylvania discovered additional human genes with properties similar to TDP-43 and FUS that might also contribute to amyotrophic lateral sclerosis.
Researchers develop first mouse model to study important aspect of Alzheimer disease
Nov 08, 2011
Researchers at the University of Georgia have found that Hirano bodies may play a protective role in the progression of neurodegenerative diseases such as Alzheimer disease. And to find out why this may be happening, they have developed the world's first transgenic mouse model that has Hirano bodies, which will open new frontiers on how these poorly understood structures may be involved with some of humankind's most difficult-to-treat diseases.
Researchers find new insight into spinal muscular atrophy
Sep 28, 2011
Researchers at the University of Missouri have identified a communication breakdown between nerves and muscles in mice that may provide new insight into the debilitating and fatal human disease known as spinal muscular atrophy. It may also may shed light on other diseases involving motor neurons, including amyotrophic lateral sclerosis, and dysfunctions of the synapses, such as Duchenne Muscular Dystrophy.
New genetic mutation for amyotrophic lateral sclerosis identified
Sep 21, 2011
A team led by scientists from Johns Hopkins and the National Institutes of Health has discovered a new genetic mutation for amyotrophic lateral sclerosis and a related disease called frontotemporal dementia that appears to account for more than a third of all inherited cases of these diseases.
Using bone marrow to protect the brain
Sep 20, 2011
A technology developed at Tel Aviv University is now out of the lab and in hospitals to begin clinical trials with patients suffering from amyotrophic lateral sclerosis.
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