Historical note and nomenclature
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By K K Jain MD

Zonisamide is chemically classified as a sulfonamide and is unrelated to other antiepileptic drugs. Originally developed in Japan for the treatment of epilepsy, it was later approved in 1989, and has since been licensed in many countries. It was under investigation for cerebral ischemia, but no development has been reported for this indication since 1994. Zonisamide was approved by the Food and Drug Administration on March 28, 2000 for marketing as another adult epilepsy treatment or therapy and a critical review of zonisamide was published at that time (Jain 2000).