Triptans, selective serotonin receptor (5-HT) agonists, are used in the treatment of acute migraine attacks as well as non-migraine headaches. In this clinical article, Dr. K K Jain describes the pharmacology of triptans and compares 7 approved triptans: almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, and zolmitriptan. Clinical trials of triptans and personalized treatment of migraine with triptans are also described.
Triptans are selective serotonin receptor agonists used in the treatment of acute migraine attacks.
The beneficial effect of triptans in migraine is related to their multiple mechanisms of action at sites implicated in the pathophysiology of migraine, eg, vasoconstriction.
Several triptans with different methods of delivery are available.
It may be possible to match individual patient needs with the specific characteristics of the individual triptans to optimize therapeutic benefit.