Toxic peripheral neuropathies

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By Michael T Pulley MD PhD

Toxic peripheral neuropathy is also known as or subsumes Angiitis and Arteritis. -ed.

In this summary, Dr. Michael Pulley of the University of Florida, Jacksonville, discusses general principles regarding toxic peripheral neuropathy. This clinical entity is most commonly encountered as an adverse effect of medications, but environmental and occupational exposure can also result in toxic neuropathy. The author gives clues to help guide the process of evaluation in patients suspected of having toxic peripheral neuropathy.

Key Points

  • Toxic neuropathy should have a temporal and dose-response relationship between symptoms and exposure.
  • There should be consistency of disease in those with similar exposures.
  • Improvement (or at least stabilization) of neuropathic symptoms should occur when exposure ceases.