Toxic peripheral neuropathies

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By Michael T Pulley MD PhD

Toxic peripheral neuropathy is also known as or subsumes Angiitis and Arteritis. -ed.

In this article, the authors discuss general principles regarding toxic peripheral neuropathy. This clinical entity is most commonly encountered as an adverse effect of medications, but environmental and occupational exposure can also result in toxic neuropathy. The authors give clues to help guide the process of evaluation in patients suspected of having toxic peripheral neuropathy.

Key Points

  • Toxic neuropathy should have a temporal and dose-response relationship between symptoms and exposure.
  • There should be consistency of disease in those with similar exposures.
  • Improvement (or at least stabilization) of neuropathic symptoms should occur when exposure ceases.

In This Article

Historical note and nomenclature
Clinical applications
References cited