Topiramate

Historical note and nomenclature
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By K K Jain MD

Topiramate is a monosaccharide derivative with a sulfamate functionality. It has multiple putative mechanisms of action. It was developed as an antiepileptic as McN-4853 and showed effectiveness against maximum electroshock in rats with a potency equal to that of phenytoin. Topiramate was commercialized and has been available in the United Kingdom since mid-1995. The United States Food and Drug Administration approved it in 1997.

In This Article

Historical note and nomenclature
Pharmacology
Clinical trials
Indications
Contraindications
Goals and duration of treatment
Dosing
Precautions and use in special groups
Interactions
Adverse effects
References cited
Contributors