Tiagabine

Indications
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By K K Jain MD

Tiagabine hydrochloride is indicated as adjunctive therapy in the treatment of partial seizures in adults and children 12 years and older.

Off-label/investigational uses.

  • Treatment of anxiety. Open-label investigations indicate that tiagabine may be a useful addition to currently available drugs for anxiety (Schwartz and Nihalani 2006; Dunlop et al 2007).
  • Epilepsy and severe impulse control disorder.
  • Results of an open-label and double-blind discontinuation trial indicate that tiagabine may be useful for the treatment of posttraumatic stress disorder (Connor et al 2006).
  • Tiagabine suppresses nocturnal bruxism when given at bedtime (Kast 2005).
  • Management of chronic pain (Todorov et al 2005).
  • A placebo-controlled screening trial indicates that tiagabine should be considered for further study as a cocaine-dependence treatment (Winhusen et al 2005).
  • Management of painful spasticity in children (Chu and Sala 2006).
  • Posttraumatic stress disorder (Davidson et al 2007).
  • Controlled studies do not support the use of tiagabine for generalized anxiety disorder (Pollack et al 2008; Zwanzger et al 2009).
  • Essential tremor (Gironell et al 2008).

In This Article

Historical note and nomenclature
Pharmacology
Clinical trials
Indications
Contraindications
Goals and duration of treatment
Dosing
Precautions and use in special groups
Interactions
Adverse effects
References cited
Contributors