Tiagabine

Historical note and nomenclature
Article section 1 of 12.  Next

By K K Jain MD

Tiagabine, as a novel antiepileptic, has a mechanism of action related to GABA. The synthesis of vigabatrin (gamma-vinyl-GABA) was a result of a rational approach to design compounds to inhibit the major GABA-degrading enzyme, GABA transaminase (Angehagen et al 2003). Whereas vigabatrin is a selective and irreversible GABA-transaminase inhibitor that greatly increases whole-brain levels of GABA, tiagabine is a potent inhibitor of GABA uptake into neurons and glial cells.

In This Article

Historical note and nomenclature
Pharmacology
Clinical trials
Indications
Contraindications
Goals and duration of treatment
Dosing
Precautions and use in special groups
Interactions
Adverse effects
References cited
Contributors