Supratentorial hemispheric low-grade gliomas of childhood are also known as or subsume Cortical gliomas and Supratentorial astrocytomas. -ed.
In this clinical article, Dr. Roger Packer of the Children's National Medical Center reviews supratentorial low-grade gliomas, which are comprised of a variety of different histological subtypes. Outcome is excellent after gross total resection, but some tumors may arise from infiltration of critical areas of brain structure where aggressive surgery is relatively contraindicated. For these lesions, radiation therapy and, in some cases, chemotherapy may be indicated. In addition, biologically based therapy utilizing molecular-targeted agents is becoming an increasing reality. Dr. Packer of Children’s National Medical Center summarizes these new approaches and the clinical implications of new biological insights. New molecular information has been added and its clinical implications discussed.