Sporadic schwannomas and neurofibromas are also known as or subsume Chitoneuroma, Neurilemmomas, and Perineural fibroblastoma. -ed.
In this clinical article, Dr. Herbert Newton of Ohio State University provides an in-depth review of the pathology, biology, clinical presentation, and treatment options for sporadic schwannomas and neurofibromas. These tumors arise from the nerve sheaths of cranial nerves, nerve roots, spinal nerves, and peripheral nerves. The most common location for schwannomas is the eighth cranial nerve, whereas neurofibromas more commonly arise along the spinal nerve roots. Maximal surgical resection is the treatment of choice for most tumors. Radiotherapy is only used in selected cases. Chemotherapy is still under investigation for therapeutic potential. Dr. Newton also reviews advances in the molecular biology and therapeutic approaches to these tumors.