Restless legs syndrome is also known as or subsumes Anxietas tibiarum and Leg jitters. -ed.
The sensory symptoms of restless legs syndrome are paresthesias and dysesthesias in the calves and legs. Descriptions of these phenomena include words such as aching, pulling, drawing, numbness, tingling, prickling, creeping, or crawling. The unpleasant sensations occur during rest and inactivity, and are worse in the late evening and when attempting to sleep. In this clinical summary, Dr. Pinky Agarwal of the Booth Gardner Parkinson Center at Evergreen Hospital Medical Center, Dr. Narendra Vaish of GenomeRx, LLC, and Dr. Sindhu R Srivatsal of the University of Washington Medical Center discuss the genetics, clinical features, diagnosis and differential diagnosis, etiology, pathophysiology, management, and prognosis of this common disorder. Management of special conditions, such as restless legs syndrome in pregnancy, are addressed as well. The current update includes recent literature on insights into the etiopathogenesis of restless legs syndrome.