Research identifies how vitamin D combats multiple sclerosis

Aug 16, 2011

While for years scientists have noted an association between levels of vitamin D in a person’s body and the person’s ability to resist or minimize the effects of multiple sclerosis, the mechanism involved has not been established. However new research appears to have uncovered that process. The study, published in the journal Molecular and Cellular Biology, finds that vitamin D directly terminates the production of a disease-causing protein.

During multiple sclerosis (EAE in mice), a damaging protein called interleukin-17 (IL-17) is produced by immune cells in the brain. The investigators, a collaborative team of scientists from the University of Medicine and Dentistry of New Jersey and Stanford University, find that after vitamin D binds to its receptor, the receptor parks itself on the gene that encodes IL-17. By doing so, the receptor occupies a site normally reserved for a protein called NFAT, which is required to turn the gene on. The gene stays off and IL-17 levels plummet.

At the same time, the vitamin D receptor turns on another gene, whose product generates suppressive T cells that combat the destructive action of their IL-17-producing counterparts.

According to the researchers, the mechanism they identify suggests what might be a new path toward pharmaceutical treatment of multiple sclerosis, as well as therapies for other autoimmune diseases that might include rheumatoid arthritis, type 1 diabetes, eczema, and psoriasis.

Source: News Release
University of Medicine and Dentistry of New Jersey (UMDNJ)
August 16, 2011