Patients suffering REM sleep behavior disorders dream nightmares in which they are attacked and pursued, with the particularity that they express them by screaming, crying, punching, and kicking while sleeping. Lancet Neurology has published the third consecutive work in 5 years about the relationship between this disorder and Parkinson disease. The first work showed in 2006 that 45% of patients who suffer this sleep disorder develop Parkinson disease and other neurodegenerative diseases caused by a lack of dopamine in the brain. The second article discovered that neuroimaging tests that measure dopamine in the brain, such as the brain SPECT, are useful to identify patients with REM sleep disorders with increased risk of developing a neurodegenerative diseases such as Parkinson disease.
The new study applied brain SPECT to conclude that the levels of dopamine in the brain are quickly lowering over the years in patients with REM sleep behavior disorder. This neuroimaging technique becomes the first tool to detect the disease progression at an early stage. The first author of the 3 articles is DrÀlex Iranzo, doctor from the Neurology Service at the Hospital Clínic of Barcelona, researcher at the Biomedical Research Institute of August Pi i Sunyer (IDIBAPS), and member of the Multidisciplinary Sleep Disorders Unit; the senior authors were Dr Joan Santamaria and Dr Eduard Tolosa, from the same institution.
The study involved comparing the evolution of brain SPECT in 20 patients with REM disorder and 20 healthy control for 3 years. The neuroimaging technique measures the presence of dopamine in the substantia nigra, a part of the brain associated with learning and harmony of body movements. In Parkinson disease a deficiency of dopamine in the substantia nigra causes tremor, stiffness, and movement slowness in patients. Results show that after 3 years of monitoring the production of dopamine in the control group was reduced by 8% due to age, while the group of REM sleep disorder patients experienced a reduction of 20%. Once the 3-year follow-up ended, 3 of 20 patients in the REM sleep disorder group had developed Parkinson disease and their dopamine reduction was around 30%.
The 3 works led by the IDIBAPS - Hospital Clínic of Barcelona team conclude that more efforts are needed to create neuroprotective drugs that prevent the progression from REM sleep behavior disorders to Parkinson disease. For the first time scientists have a technique, brain SPECT, to evaluate whether these drugs are effective. Authors of the study suggest that, to be considered effective, a neuroprotective drug should significantly prevent the dopamine concentration from dropping in these patients.
Source: News Release
IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
July 29, 2011