Progressive subcortical gliosis

Prognosis and complications
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By Douglas J Lanska MD MS MSPH

The course is progressive, generally over 5 to 15 years, but both fulminant (3 months to 2 years) and protracted (spanning decades) courses occur. The duration of illness is generally longer in familial cases than in sporadic cases. The most common causes of death are pneumonia, other respiratory infections, and pulmonary emboli.

Overall, the survival of patients with progressive subcortical gliosis is similar to that of other types of frontotemporal dementia (Chiu et al 2010).

In This Article

Introduction
Historical note and nomenclature
Clinical manifestations
Clinical vignette
Etiology
Pathogenesis and pathophysiology
Epidemiology
Differential diagnosis
Diagnostic workup
Prognosis and complications
Management
References cited
Contributors