In post-polio syndrome, symptoms occur several decades after recovery, after a long latent period. Use of pharmacological agents in post-polio syndrome thus far has been disappointing. It is hoped that support from the polio clinic may result in self-selected lifestyle changes, which may positively influence the development of symptoms and functional capacity. Patient education, health promotion, and energy conservation strategies that include walking with a properly fitting assistive device reduce perceived fatigue and improve posture and function in an individual with post-polio syndrome. Future randomized trials should also address the long-term effects of muscular training in post-polio syndrome, in addition to treatment of pain in these patients. Randomized control studies had shown that intravenous immunoglobulin is effective to reduce pain in complex regional pain syndrome (low-dose intravenous immunoglobulin) and post-polio syndrome (high-dose intravenous immunoglobulin). Open trials have also shown efficacy in additional pain conditions. But questions still linger around the optimal treatment doses, duration of treatment, and its effect on function and quality of life.