Paraneoplastic syndromes

Epidemiology
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By Edward J Dropcho MD

Many types of tumors have been associated with paraneoplastic disorders, but for most paraneoplastic neurologic syndromes, an overrepresentation of 1 or a few particular neoplasms is seen (Giometto et al 2010). Neuroblastoma and small-cell lung carcinoma are the tumors most often associated with paraneoplastic phenomena in children and adults, respectively. Paraneoplastic opsoclonus-myoclonus occurs in 2% to 3% of children with neuroblastoma. Paraneoplastic disorders occurring in association with other childhood tumors are rare. Approximately 1% to 3% of patients with small cell lung carcinoma develop Lambert-Eaton myasthenic syndrome or another paraneoplastic syndrome (Seute et al 2004). Other tumors overrepresented among patients with paraneoplastic syndromes include breast carcinoma, ovarian carcinoma, ovarian teratoma, Hodgkin lymphoma, thymoma, and testicular germ cell tumors.

In This Article

Introduction
Historical note and nomenclature
Clinical manifestations
Etiology
Pathogenesis and pathophysiology
Epidemiology
Prevention
Differential diagnosis
Diagnostic workup
Prognosis and complications
Management
Anesthesia
References cited
Contributors