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By K K Jain MD

“Neuroproteomics” is the term used for application of proteomics to the study of the nervous system and its disorders with the aim of developing diagnostics and therapeutics. In this clinical article, Dr. K K Jain, a consultant in neurology from Basel, Switzerland, describes the application of proteomic technologies and the development of tests for neurologic disorders by examining proteins in blood and urine. Because proteins are the targets for action of most drugs, an insight into protein-based mechanisms of neurologic disorders will enable discovery of more relevant drugs for central nervous system disorders.

Key points

  • Neuroproteomics, the application of proteomics to the study of the nervous system, is making an important contribution to understanding the pathomechanism of neurologic disorders.
  • Discovery of protein biomarkers of neurologic disorders is a basis for diagnosis, monitoring of disease, as well as development of drugs.
  • Neuroproteomics has made important contributions to study of neurodegenerative disorders, particularly Alzheimer disease, in which a protein-based reliable test has been developed to diagnose the disease from cerebrospinal fluid examination.