Neuropathic pain: treatment

Introduction
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By Yi Pan MD PhD and Florian P Thomas MD MA PhD

Treatment of neuropathic pain is an ongoing challenge for clinicians. In this article, the authors summarize pharmacological management based on published clinical trials. Not all medications mentioned in this article have been investigated in placebo-controlled, double-blind, randomized trials. The aim of this article is to provide a variety of updated information for clinicians to choose an optimal treatment for an individual patient.

Key points

  • Neuropathic pain is frequently treated with antidepressants, anticonvulsants, antiarrhythmics, topical agents, and analgesics.
  • The treatment must be individualized.
  • Combination of different agents should be considered in some patients.
  • Slow dose escalation may improve drug tolerability.

In This Article

Introduction
Historical note and nomenclature
Scientific basis
Indications
Contraindications
Goals and endpoint
Description
Outcome
Adverse effects
Prognosis
Clinical vignette
Pregnancy
References cited
Contributors