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By Jessica Ailani MD

Migraine is also known as or subsumes Blinding headache. -ed.

Migraine is a common, frequently incapacitating headache disorder characterized by episodic attacks of moderate to severe headaches, and various combinations of neurologic, gastrointestinal, and/or autonomic nervous systemic dysfunction. Migraine imposes a substantial burden on the individual patient and society. The last 2 decades have witnessed significant advances in the field of migraine. In this clinical article, Dr. Jessica Ailani of the Georgetown Headache Center at Georgetown University Hospital in Washington, DC outlines the current understanding of migraine pathophysiology and the evolving therapeutic strategies in migraine treatment. New genetic advancements and an update on risk factors related to migraine are reviewed.