Medulloblastoma

Introduction
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By Roger Packer MD

Medulloblastoma is also known as or subsumes Primitive neuroectodermal tumor of the posterior fossa. -ed.

Medulloblastoma is the most common malignant childhood brain tumor. There has been a marked improvement in overall survival for patients with this tumor, but a major challenge remains quality-of-life for survivors. There has also been an explosion in the understanding of the neurobiology of the tumor, and in this clinical summary, Dr. Packer of Children’s National Medical Center has attempted to capture the potential clinical significance of these new molecular discoveries, how they will be incorporated into care, and the challenges that lie ahead.

In This Article

Introduction
Historical note and nomenclature
Clinical manifestations
Clinical vignette
Etiology
Pathogenesis and pathophysiology
Epidemiology
Prevention
Differential diagnosis
Diagnostic workup
Prognosis and complications
Management
References cited
Contributors