Lennox-Gastaut syndrome is also known as or subsumes Akinetic epilepsy, Cryptogenic Lennox-Gastaut syndrome, Symptomatic Lennox-Gastaut syndrome. -ed.
Lennox-Gastaut syndrome is diagnosed in individuals with intractable epilepsy characterized by multiple seizure types, slow spike-wave pattern on EEG, and cognitive deterioration typically after first seizure onset. Seizure types include tonic seizures that mainly occur in sleep, atonic seizures, atypical absences, and myoclonic seizures. The condition may follow West syndrome, but has also been associated with various genetic and neurocutaneous syndromes, metabolic diseases, early infectious or ischemic insults, or may have an unknown etiology. Numerous interventions as well as medications have been studied in treating this condition, most recently clobazam, which may be effective in controlling drop attacks.