Headache associated with neurologic deficits and CSF lymphocytosis (HaNDL) is also known as or subsumes Pseudomigraine. -ed.
Headache associated with neurologic deficits and cerebrospinal fluid lymphocytosis (HaNDL), also known as pseudomigraine with pleocytosis, is a benign but spectacular syndrome of unknown etiology combining headache, focal neurologic symptoms, and lymphocytic pleocytosis, usually in young to middle-aged men. In this clinical article, Dr. Julio Pascual, Director of the Neuroscience Area at the University Hospital Central de Asturias in Oviedo, Spain, reviews the history, clinical manifestations, and practical management of this condition. Particular attention is given to the clinical clues and the role of neuroimaging techniques for its diagnosis.