This clinical article includes discussion of headaches associated with alcohol, MSG (monosodium glutamate), nitrates. Substance-use headaches may also be known by such terms as Hot dog headache and Chinese restaurant headache.
Substance headache is a headache that develops de novo with the use or exposure of a substance. The clinical manifestations of substance-induced headache are variable. In this clinical summary, Dr. Chen of the National Yang-Ming University School of Medicine and Neurological Institute at Taipei Veterans General Hospital in Taipei, Taiwan, updates the current evidence regarding the clinical manifestations and pathophysiology of headache associated with the acute use or exposure of certain substances, with specific focus on nitric oxide donor and carbon monoxide, which provides a better understanding of headache biology.