Febrile seizures

References cited
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By Renée Shellhaas MD MS, Carol S Camfield MD, and Peter Camfield MD

Akbayram S, Cemek M, Buyukben A, et al. Major and minor bio-element status in children with febrile seizure. Bratisl Les Listy 2012;113:421-3.

American Academy of Family Physicians. Information from your family doctor. Febrile seizures: what you should know. American Family Physician 2006;73(10):1765-6.

American Academy of Pediatrics. Provisional Committee on Quality Improvement, Subcommittee on Febrile Seizures. Practice parameter: the neurodiagnostic evaluation of the child with a first simple febrile seizure. Pediatrics 1996;97(5):769-72; discussion 773-5.

American Academy of Pediatrics. Steering Committee on Quality Improvement and Management, Subcommittee on Febrile Seizures. Febrile Seizures: Clinical Practice Guideline for the Long-term Management of the Child With Simple Febrile Seizures. Pediatrics 2008;121(6):1281-6.

American Academy of Pediatrics, Subcommittee on Febrile Seizures. Neurodiagnostic evaluation of the child with a simple febrile seizure. Pediatrics 2011;127(2):389-94.

Annegers JF, Hauser WA, Anderson VE, Kurland LT. The risks of seizure disorders among relatives of patients with childhood onset epilepsy. Neurology 1982;32(2):174-9.

Annegers JF, Hauser WA, Shirts SB, Kurland LT. Factors prognostic of unprovoked seizures after febrile convulsions. N Engl J Med 1987;316:494-8.

Barlow WE, Davis RL, Glasser JW, et al. The risk of seizures after receipt of whole-cell pertussis or measles, mumps, and rubella vaccine. N Engl J Med 2001;345(9):656-61.

Bassan H, Barzilay M, Shinnar S, Shorer Z, Matoth I, Gross-Tsur V. Prolonged febrile seizures, clinical characteristics, and acute management. Epilepsia 2013;54(6):1092-8.

Berg AT, Shinnar S. Complex febrile seizures. Epilepsia 1996;37:126-33.

Berg AT, Shinnar S, Darefsky AS, et al. Predictors of recurrent febrile seizures: a prospective cohort study. Arch Pediatr Adolesc Med 1997;151(4):371-8.

Berg AT, Shinnar S, Hauser WA. Predictors of recurrent febrile seizures: a prospective study of the circumstances surrounding the initial febrile seizure. N Engl J Med 1992;327:1122-7.

Berg AT, Shinnar S, Hauser WA, Leventhal JM. Predictors of recurrent febrile seizures: a metaanalytic review. J Pediatr 1990;116(3):329-37.

Berkovic SF, Scheffer IE. Febrile seizures: genetics and relationship to other epilepsy syndromes. Curr Opin Neurol 1998;11:129-34.

Bethune P, Gordon KG, Dooley JM, Camfield CS, Camfield PR. Which child will have a febrile seizure? Am J Dis Child 1993;147:35-9.

Brewster A, Bender RA, Chen Y, Dube C, Eghbal-Ahmadi M, Baram TZ. Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner. J Neurosci 2002;22(11):4591-9.

Callegaro S, Titomanlio L, Donegà S, et al. Implementation of a febrile seizure guideline in two pediatric emergency departments. Pediatr Neurol 2009;40:78-83.

Camfield CS, Camfield PR, Smith E, Dooley JM. Home use of rectal diazepam to prevent status epilepticus in children with convulsive disorders. J Child Neurol 1989;4:125-6.

Camfield PR, Camfield CS, Gordon K, Dooley JM. What types of epilepsy are preceded by febrile seizures? A population based study of children. Dev Med Child Neurol 1994;36:887-92.

Camfield PR, Camfield CS, Gordon K, Dooley JM. Prevention of recurrent febrile seizures. J Pediatr 1995;126(6):929-30.

Camfield PR, Camfield CS, Hirtz DH. Treatment of febrile seizures. In: Engel J Jr, Pedley TA, editors. Epilepsy: a comprehensive textbook. Philadelphia: Lippincott-Raven, 1997:1305-9.

Camfield PR, Camfield CS, Shapiro SH, Cummings C. The first febrile seizure--antipyretic instruction plus either phenobarbital or placebo to prevent a recurrence. J Pediatr 1980;97(1):16-21.

Capovilla G, Mastrangelo M, Romeo A, Vigevano F. Recommendations for the management of “febrile seizures”: ad hoc Task Force of LICE Guidelines Commission. Epilepsia 2009;50(Suppl 1):2-6.

Chang YC, Guo NW, Wang ST, Huang CC, Tsai JJ. Working memory of school-aged children with a history of febrile convulsions: a population study. Neurology 2001;57(1):37-42.

Choi J, Min HJ, Shin JS. Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures. J Neuroinflammation 2011;8:135.

Chou IC, Lin WD, Wang CH, Tsai CH, Li TC, Tsai FJ. Interleukin (IL)-1beta, IL-1 receptor antagonist, IL-6, IL-8, IL-10, and tumor necrosis factor alpha gene polymorphisms in patients with febrile seizures. J Clin Lab Anal 2010;24(3):154-9.

Chung B, Wong V. Relationship between five common viruses and febrile seizure in children. Arch Dis Child 2007;92(7):589-93.

Committee on Infectious Diseases. Policy Statement—Prevention of Varicella: Update of recommendations for use of quadrivalent and monovalent varicella vaccines in children. Pediatrics 2011;128:630-2.

Dai YJ, Xu ZH, Feng B, et al. Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures. Neurosci Bull 2014;30(6):913-22.

Dibbens LM, Reid CA, Hodgson B, et al. Augmented currents of an HCN2 variant in patients with febrile seizure syndromes. Ann Neurol 2010;67(4):542-6.

Eckhaus J, Lawrence KM, Helbig I, et al. Genetics of febrile seizure subtypes and syndromes: a twin study. Epilepsy Research 2013;105(1-2):103-9.

Egri C, Vilin YY, Ruben PC. Thermoprotective role of the sodium channel ß1 subunit is lost with the ß1 (C121W) mutation. Epilepsia 2012;53(3):494-505.

Ellenberg JH, Nelson KB. Febrile seizures and later intellectual performance. Arch Neurol 1978;35:17-21.

Emsley HC, Appleton RE, Whitmore CL, et al. Variations in inflammation-related genes may be associated with childhood febrile seizure susceptibility. Seizure 2014;23(6):457-61.

Engel J Jr; International League Against Epilepsy (ILAE). A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia 2001;42(6):796-803.

Epstein LG, Shinnar S, Hesdorffer DC, et al. Human herpesvirus 6 and 7 in febrile status epilepticus: the FEBSTAT study. Epilepsia 2012;53(9):1482-8.

Fauser S, Huppertz HJ, Bast T, et al. Clinical characteristics in focal cortical dysplasia: a retrospective evaluation in a series of 120 patients. Brain 2006;129(7):1907-16.

Feenstra B, Pasternak B, Geller F, et al. Common variants associated with general and MMR vaccine-related febrile seizures. Nat Genet 2014;46(12):1274-82.

Frank LM, Shinnar S, Hesdorffer DC, et al. Cerebrospinal fluid findings in children with fever-associated status epilepticus: results of the consequences of prolonged febrile seizures (FEBSTAT) study. J Pediatr 2012;161:1169-71.

Freeman JM. Febrile seizures: long-term management of children with fever-associated seizures. Pediatrics 1980;66:1009-12.

Frobert E, Sarret C, Billaud G, et al. Pediatric neurological complications associated with the A(H1N1)pdm09 influenza infection. J Clin Virol 2011;52(4):307-13.

Fukuda M, Suzuki Y, Ishizaki Y, et al. Interleukin-1beta enhances susceptibility to hyperthermia-induced seizures in developing rats. Seizure 2009;18(3):211-4.

Ganesh R, Janakiraman L. Serum zinc levels in children with simple febrile seizure. Clin Pediatr (Phila) 2008;47(2):164-6.

Gerber MA, Berliner BC. The child with a "simple" febrile seizure. Appropriate diagnostic evaluation. Am J Dis Child 1981;135:431-3.

Gordon KE, Camfield PR, Camfield CS, Dooley JM, Bethune P. Children with febrile seizures do not consume excess health care resources. Arch Pediatr Adolesc Med 2000;154(6):594-7.

Gordon KE, Dooley JM, Wood EP, Bethune P. Is temperature regulation different in children susceptible to febrile seizures? Can J Neurol Sci 2009;36:192-5.

Günes S, Dirik E, Yis U, et al. Oxidant status in children after febrile seizures. Pediatr Neurol 2009;40:47-9.

Hampers LC, Thompson DA, Bajaj L, Tseng BS, Rudolph JR. Febrile seizure: measuring adherence to AAP guidelines among community ED physicians. Pediatr Emerg Care 2006;22(7):465-9.

Hara K, Tanabe T, Aomatsu T, et al. Febrile seizures associated with influenza A. Brain Dev 2007;29(1):30-8.

Harder KM, Molbak K, Glismann S, Christiansen AH. Influenza-associated illness is an important contributor to febrile convulsions in Danish children. J Infect 2012;64:520-4.

Haspolat S, Baysal Y, Duman O, Coskun M, Yegin O. Interleukin-1alpha, interleukin-1beta, and interleukin-1Ra polymorphisms in febrile seizures. J Child Neurol 2005;20:565-8.

Hesdorffer DC, Benn EK, Bagiella E, et al. Distribution of febrile seizure duration and associations with development. Ann Neurol 2011;70(1):93-100.

Hesdorffer DC, Chan S, Tian H, et al. Are MRI-detected brain abnormalities associated with febrile seizure type? Epilepsia 2008;49:765-71.

Hesdorffer DC, Shinnar S, Lewis DV, et al. Design and phenomenology of the FEBSTAT study. Epilepsia 2012;53;1471-80.

Hirabayashi Y, Okumura A, Kondo T, et al. Efficacy of a diazepam suppository at preventing febrile seizure recurrence during a single febrile illness. Brain Dev 2009;31:414-8.

Hirtz DG. Generalized tonic-clonic and febrile seizures. Pediatr Clin North Am 1989;36:365-82.

Hirtz DG, Camfield CS, Camfield PR. Febrile convulsions. In: Engel J Jr, Pedley TA, editors. Epilepsy: a comprehensive textbook. Philadelphia: Lippincott-Raven, 1997:2483-8.

Hirtz DG, Nelson KB. The natural history of febrile seizures. Ann Rev Med 1983;34:453-71.

Hirtz DG, Nelson KB, Ellenberg JH. Seizures following childhood immunizations. J Pediatr 1983;120(1):14-8.

Holtzman D, Obana K, Olson J. Hyperthermia-induced seizures in the rat pup: a model for febrile convulsions in children. Science 1981;213:1034-6.

Huang MC, Liu CC, Chi YC, Huang CC, Cain K. Parental concerns for the child with febrile convulsion: long-term effects of educational interventions. Acta Neurol Scand 2001;103(5):288-93.

Huang MC, Liu CC, Huang CC, Thomas K. Parental responses to first and recurrent febrile convulsions. Acta Neurol Scand 2002;105(4):293-9.

Idro R, Gwer S, Williams TN, et al. Iron deficiency and acute seizures: results from children living in rural Kenya and a meta-analysis. PLoS One 2010;5(11): e14001.

Ishizaki Y, Kira R, Fukuda M, et al. Interleukin-10 is associated with resistance to febrile seizures: genetic association and experimental animal studies. Epilepsia 2009;50(4):761-7.

Jacobsen SJ, Ackerson BK, Sy LS, et al. Observational safety study of febrile convulsion following first dose MMRV vaccination in a managed care setting. Vaccine 2009;27:4656-61.

Jenssen FE, Sanchez RM. Why does the developing brain demonstrate heightened susceptibility to febrile and other provoked seizures? In: Baran TZ, Shinnar S, editors. Febrile seizures. San Diego: Academic Press, 2002:153-68.

Joshi C, Wawrykow T, Patrick J, Prasad A. Do clinical variables predict an abnormal EG in patients with complex febrile seizures? Seizure 2005;14:429-34.

Ju HO, McElmurry BJ, Park CG, McCreary L, Kim M, Kim EJ. Anxiety and uncertainty in Korean mothers of children with febrile convulsion: cross-sectional survey. J Clin Nurs 2011;20(9-10):1490-7.

Kanemoto K, Kawasaki J, Yuasa S, et al. Increased frequency of interleukin-1beta-511T allele in patients with temporal lobe epilepsy, hippocampal sclerosis, and prolonged febrile convulsion. Epilepsia 2003;44(6):796-9.

Kang B, Kim DH, Hong JY, et al. Comparison between febrile and afebrile seizures associated with mild rotavirus gastroenteritis. Seizure 2013;22(7):560-564.

Kang JQ, Shen W, Macdonald RL. Why does fever trigger febrile seizures? GABAA receptor gamma2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. J Neurosci 2006;26(9):2590-7.

Kelly H, Carcione D, Dowse G, Effler P. Quantifying benefits and risks of vaccinating Australian children aged six months to four years with trivalent inactivated seasonal influenza vaccine in 2010. Euro Surveill 2010;15(37):pii:19661.

Khosroshahi N, Faramarzi F, Salamati P, Haghighi SM, Kamrani K. Diazepam versus clobazam for intermittent prophylaxis of febrile seizures. Indian J Pediatr 2011;78(1):38-40.

Kimia A, Ben-Joseph EP, Rudloe T, et al. Yield of lumbar puncture among children who present with their first complex febrile seizure. Pediatrics 2010;126(1):62-9.

Kimia AA, Caparo AJ, Hummel D, Johnston P, Harper MB. Utility of lumbar puncture for first simple febrile seizure among children 6 to 18 months of age. Pediatrics 2009;123:6-12.

Kira R, Ishizaki Y, Torisu H, et al. Genetic susceptibility to febrile seizures: case-control association studies. Brain Dev 2010;32(1):57-63.

Kira R, Torisu H, Takemoto M, et al. Genetic susceptibility to simple febrile seizures: interleukin-1beta promoter polymorphisms are associated with sporadic cases. Neurosci Lett 2005;384:239-44.

Klein NP, Fireman B, Yih WK, et al; Vaccine Safety Datalink. Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures. Pediatrics 2010;126(1):e1-8.

Knudsen FU, Vestermark S. Prophylactic diazepam or phenobarbitone in febrile convulsions: a prospective, controlled study. Arch Dis Child 1978;53:660-3.

Kolhai AA, Tahmooreszadeh S. First febrile convulsions: inquiry about the knowledge, attitudes and concerns of the patients’ mothers. Eur J Pediatr 2009;168:167-71.

Laina I, Syriopoulou VP, Daikos GL, et al. Febrile seizures and primary human herpesvirus 6 infection. Pediatr Neurol 2010;42(1):28-31.

Lau SK, Woo PC, Yip CC, et al. Coronavirus HKU1 and other coronavirus infections in Hong Kong. J Clin Microbiol 2006;44(6):2063-71.

Leaffer EB, Hinton VJ, Hesdorffer DC. Longitudinal assessment of skill development in children with first febrile seizure. Epilepsy Behav 2013;28(1):83-7.

Lee W, Ong H. Afebrile seizures associated with minor infections: comparison with febrile seizures and unprovoked seizures. Pediatr Neurol 2004;31(3):157-64.

Lennox MA. Febrile convulsions in childhood: their relationship to adult epilepsy. J Pediatr 1949;35:427-35.

Le Saux, Barrowman N, Moore D, et al. Decrease in hospital admissions for febrile seizures and reports of hypotonic-hyporesponsive episodes presenting to hospital emergency departments since switching to acellular pertussis vaccine in Canada: a report from IMPACT. Pediatrics 2003;112(5):e348.

Lewis DV, Shinnar S, Hesdorffer DC, et al. Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study. Ann Neurol 2014;75(2):178-85.

Lewis HM, Parry JV, Parry RP, et al. Role of viruses in febrile convulsions. Arch Dis Child 1979;54:869-76.

Livingston S, Bridge EM, Kajdi L. Febrile convulsions: a clinical study with special reference to heredity and prognosis. J Pediatr 1947;31:509-12.

Maglione MA, Das L, Raaen L, et al. Safety of vaccines used for routine immunization of US children: a systematic review. Pediatrics 2014;134(2):325-37.

Mahyar A, Ayazi P, Fallahi M, Javadi A. Correlation between serum selenium level and febrile seizures. Pediatr Neurol 2010;43(5):331-4.

Maksikharin A, Prommalikit O. Serum sodium levels do not predict recurrence of febrile seizures within 24 hours. Paediatr Int Child Health 2015;35(1):44-6.

Mamelle N, Pleasse JC, Revol M, Gilly R. Prevention of recurrent febrile convulsions--a randomized therapeutic assay: sodium valproate, phenobarbital and placebo. Neuropediatrics 1984;15:37-42.

Martin ET, Kerin T, Christakis DA, et al. Redefining outcome of first seizures by acute illness. Pediatrics 2010;126(6):e1477-84.

Matsuo M, Sasaki K, Ichimaru T, Nakazato S, Hamasaki Y. Increased IL-1beta production from dsRNA-stimulated leukocytes in febrile seizures. Pediatr Neurol 2006;35(2):102-6.

McCaughran JA Jr, Schechter N. Experimental febrile convulsions: long-term effects of hyperthermia-induced convulsions in the developing rat. Epilepsia 1982;23:173-83.

Millichap JJ, Gordon Millichap J. Methods of investigation and management of infections causing febrile seizures. Pediatr Neurol 2008;39:381-6.

Mollah MA, Rakshit SC, Anwar KA, et al. Zinc concentrations in serum and cerebrospinal fluid simultaneously decrease in children with febrile seizure: findings from a prospective study in Bangladesh. Acta Paediatrica 2008;97:1707-11.

Nakayama J, Arinami T. Molecular genetics of febrile seizures. Epilepsy Res 2006;70(Suppl 1):S190-8.

National Institute of Neurological Disorders and Stroke. NINDS febrile seizures information page. Available at: http://www.ninds.nih.gov/disorders/febrile_seizures/febrile_seizures.htm. Last updated February 1, 2013.

Nelson KB, Ellenberg JH. Predictors of epilepsy in children who have experienced febrile seizures. N Engl J Med 1976;295(19):1029-33.

Nelson KB, Ellenberg JH. Prognosis in children with febrile seizures. Pediatrics 1978;61:720-77.

Newman J. Evaluation of sponging to reduce body temperature in febrile children. Can Med Assoc J 1985;132:641-2.

Nordli DR Jr, Moshé SL, Shinnar S, et al. Acute EEG findings in children with febrile status epilepticus. Neurology 2012;79:2180-6.

Nørgaard M, Ehrenstein V, Mahon BE, Nielsen GL, Rothman KJ, Sørensen HT. Febrile seizures and cognitive function in young adult life: a prevalence study in Danish conscripts. J Pediatr 2009;155:404-9.

O’Dell C, Shinnar S, Ballaban-Gil KR, et al. Rectal diazepam gel in home management of seizures in children. Pediatr Neurol 2005;33:166-72.

Offringa M, Derksen-Lubsen G, Bossuyt PM, Lubsen J. Seizure recurrence after a first febrile seizure: a multivariate approach. Dev Med Child Neurol 1992;34:15-24.

Offringa M, Moyer VA. Evidence based paediatrics: evidence based management of seizures associated with fever. BMJ 2001;323(7321):1111-4.

Offringa M, Newton R. Prophylactic drug management for febrile seizures in children. Cochrane Database of Syst Rev 2012 Apr 18;4:CD003031.

Offringa M, Newton R. Prophylactic drug management for febrile seizures in children. Evid Based Child Health 2013;8(4):1376-485.

Okumura A, Uemura N, Suzuki M, Itomi K, Watanabe K. Unconsciousness and delirious behavior in children with febrile seizures. Pediatr Neurol 2004;30(5):316-9.

O’Leary ST, Suh CA, Marin M, the Vaccine Policy Collaborative Initiative. Febrile seizures and measles-mumps-rubella-varicella (MMRV) vaccine: what do primary care physicians think? Vaccine 2012;30:6731-3.

Ozkan M, Tuygun N, Erkek N, Aksoy A, Yildiz YT. Neurologic manifestations of novel influenza A (H1N1) virus infection in childhood. Pediatr Neurol 2011;45(2):72-6.

Park KI, Chu K, Jung KH, et al. Role of cortical dysplasia in epileptogenesis following prolonged febrile seizure. Epilepsia 2010;51(9):1809-19.

Pavlidou E, Panteliadis C. Prognostic factors for subsequent epilepsy in children with febrile seizures. Epilepsia 2013;54(12):2101-7.

Pavlidou E, Tzitiridou M, Kontopoulos E, Panteliadis CP. Which factors determine febrile seizure recurrence? A prospective study. Brain Dev 2008;30(1):7-13.

Pavlidou E, Tzitiridou M, Panteliadis C. Effectiveness of intermittent diazepam prophylaxis in febrile seizures: long-term prospective controlled study. J Child Neurol 2006;21(12):1036-40.

Radzicki D, Yau HJ, Pollema-Mays SL, et al. Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures. J Neurosci 2013;33(24):9920-31.

Rocca WA, Sharbrough FW, Hauser WA, Annegers JF, Schoenberg BS. Risk factors for generalized tonic-clonic seizures: a population-based case control study in Rochester, Minnesota. Neurology 1987;37:1315-22.

Rosman NP, Colton T, Labazzo J, et al. A controlled trial of diazepam administered during febrile illnesses to prevent recurrence of febrile seizures. N Engl J Med 1993;329:79-84.

Rosenbloom E, Finkelstein Y, Adams-Webber T, Kozer E. Do antipyretics prevent the recurrence of febrile seizures in children? A systematic review of randomized controlled trials and meta-analysis. Eur J Paediatr Neurol 2013;17(6):585-8.

Rowhani-Rahbar A, Fireman B, Lewis E, et al. Effect of age on the risk of fever and seizures following immunization with measles-containing vaccines in children. JAMA Pediatr 2013;167(12):1111-7.

Sakai R, Okumura A, Shimizu T, Marui E. Current explanations regarding febrile seizures provided by paediatricians in Tokyo. Dev Med Child Neurol 2009;51:651-4.

Salam SM, Rahman HM, Karam RA. GABRG2 gene polymorphisms in Egyptian children with simple febrile seizures. Indian J Pediatr 2012;79(11):1514-6.

Schuchmann S, Hauck S, Henning S, et al. Respiratory alkalosis in children with febrile seizures. Epilepsia 2011;52(11):1949-55.

Schuchmann S, Schmitz D, Rivera C, et al. Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis. Nat Med 2006;12(7):729-30.

Scott RC, King MD, Gadian DG. Prolonged febrile seizures are associated with hippocampal vasogenic edema and developmental changes. Epilepsia 2006;47(9):1493-8.

Seinfeld S, Shinnar S, Sun S, et al. Emergency management of febrile status epilepticus: results of the FEBSTAT study. Epilepsia 2014;55(3):388-95.

Serdaroglu G, Alpman A, Tosun A, et al. Febrile seizures: interleukin 1β and interleukin-1 receptor antagonist polymorphisms. Pediatr Neurol 2009;40:113-6.

Shah PB, James S, Elayaraja S. EEG for children with complex febrile seizures Cochrane Database Syst Rev 2014;1:CD009196.

Shah SS, Alpern ER, Zwerling L, Reid JR, McGowan KL, Bell LM. Low risk of bacteremia in children with febrile seizures. Arch Pediatr Adolesc Med 2002;156(5):469-72.

Shaked O, Pena BM, Linares MY, Baker RL. Simple febrile seizures: are the AAP guidelines regarding lumbar puncture being followed? Pediatr Emer Care 2009;25:8-11.

Shinnar S, Bello JA, Chan S, et al. MRI abnormalities following febrile status epilepticus in children (the FEBSTAT study). Neurology 2012;79:871-7.

Shinnar S, Hesdorffer DC, Nordli DR, et al. Phenomeology of prolonged febrile seizures: results of the FEBSTAT study. Neurology 2008;71:170-6.

Sillanpää M, Suominen S, Rautava P, Aromaa M. Academic and social success in adolescents with previous febrile seizures. Seizure 2011;20(4):326-30.

Stevenson JB. Fits and faints. Oxford: MacKeith Press, 1990.

Strengell T, Uhari M, Tarkka R, et al. Antipyretic agents for preventing recurrences of febrile seizures. Arch Pediatr Adolesc Med 2009;163:799-804.

Sun Y, Christensen J, Hviid A, et al. Risk of febrile seizures and epilepsy after vaccination with diphtheria, tetanus, acellular pertussis, inactivated poliovirus, and Haemophilus Influenzae type b. JAMA 2012;307:823-31.

Suga S, Suzuki K, Ihira M, et al. Clinical characteristics of febrile convulsions during primary HHV-6 infection. Arch Dis Child 2000;82(1):62-6.

Tartof SY, Tseng HF, Liu IL, et al. Inpatient admission for febrile seizure and subsequent outcomes do not differ in children with vaccine-associated versus non-vaccine associated febrile seizures. Vaccine 2014;32(48):6408-14.

Teng D, Dayan P, Tyler S, et al. Risk of intracranial pathologic conditions requiring emergency intervention after a first complex febrile seizure episode among children. Pediatrics 2006;117(2):304-8.

Thoman J, Duffner P, Shucard J. Do serum sodium levels predict recurrent febrile seizures within 24 hours? Pediatr Neurol 2004;31(5):342-4.

Todd E, Gurba KN, Botzolakis EJ, Stanic AK, Macdonald RL. GABAa receptor biogenesis is impaired by the γ2 subunit febrile seizure-associated mutation, GABRG2(R177G). Neurobiol Dis 2014;69:215-24.

Tomoum HY, Badawy NM, Mostafa AA, Harb MY. Plasma interleukin-1beta levels in children with febrile seizures. J Child Neurol 2007;22(6):689-92.

Tripathi M, Padhy UP, Vibha D, et al. Predictors of refractory epilepsy in north India: a case-control study. Seizure 2011;20(10):779-83.

Tsai FJ, Hsieh YY, Chang CC, Lin CC, Tsai CH. Polymorphisms for interleukin-1beta exon 5 and interleukin 1 receptor antagonist in Taiwanese children with febrile convulsions. Arch Pediatr Adolesc Med 2002;156(6):545-8.

Tsuboi T, Endo S. Genetic studies of febrile convulsions: analysis of twin and family data. Epilepsy Res 1991;4(Suppl):119-28.

Uhari M, Rantala H, Vainionpaa, Kurttila BM. Effect of acetaminophen and of low dose intermittent diazepam on prevention of recurrences of febrile seizures. J Pediatr 1995;126:991-5.

van der Berg BJ, Yerushalmy J. Studies on convulsive disorders in young children. I. Incidence of febrile and non-febrile convulsions by age and other factors. Pediatr Res 1969;2:298-304.

van Esch A, Steyerberg EW, Berger MY, et al. Family history and recurrence of febrile seizures. Arch Dis Child 1994;70:395-599.

van Stuijvenberg M, de Vos S, Tjiang GC, et al. Parents’ fear regarding fever and febrile seizures. Acta Paediatr 1999;88(6):618-22.

van Stuijvenberg M, Derksen-Lubsen G, Steyerberg EW, Habbema JD, Moll HA. Randomized, controlled trial of ibuprofen syrup administered during febrile illnesses to prevent febrile seizure recurrences. Pediatrics 1998;102(5):E51

Verbeek NE, Jansen FE, Vermeer-de Bondt PE, et al. Etiologies for seizures around the time of vaccination. Pediatrics 2014;134(4):658-66.

Verity CM, Butler NR, Golding J. Febrile convulsions in a national cohort followed up from birth. I. Prevalence and recurrence in the first five years of life. Br Med J 1985a;290:1307-10.

Verity CM, Butler NR, Golding J. Febrile convulsions in a national cohort followed up from birth. II. Medical history and intellectual ability at 5 years of age. Br Med J 1985b;290:1311-5.

Verity CM, Golding J. Risk of epilepsy after febrile convulsions: a national cohort study. BMJ 1991;303(6814):1373-6.

Verrotti A, Moavero R, Vigevano F, et al. Long-term follow-up in children with benign convulsions associated with gastroenteritis. Eur J Paediatr Neurol 2014;18(5):572-7.

Verrotti A, Nanni G, Agostinelli S, et al. Benign convulsions associated with mild gastroenteritis: A multicenter clinical study. Epilepsy Res 2011;93(2-3):107-14.

Vestergaard M, Basso, Henriksen TB, Ostergaard J, Olsen J. Febrile convulsions and sudden infant death syndrome. Arch Dis Child 2002;86(2):125-6.

Vestergaard M, Christensen J. Register-based studies on febrile seizures in Denmark. Brain Dev 2009;31:372-7.

Vestergaard M, Pedersen MG, Ostergaard JR, Pedersen CB, Olsen J, Christensen J. Death in children with febrile seizures: a population-based cohort study. Lancet 2008;372:457-63.

Virta M, Hurme M, Helminen M. Increased plasma levels of pro- and anti-inflammatory cytokines in patients with febrile seizures. Epilepsia 2002;43(8):920-3.

Visser AM, Jaddoe VW, Breteler MM, Hofman A, Moll HA, Arts WF. Frequent fever episodes and the risk of febrile seizures: the generation R Study. Eur J Paediatr Neurol 2012;16(1):29-34.

Walsh AM, Edwards HE, Courtney MD, Wilson JE, Monaghan SJ. Fever management: paediatric nurses’ knowledge, attitudes and influencing factors. J Adv Nurs 2005;49:453-64.

Webb DW, Jones RR, Manzur AY, Farrell K. Retrospective study of late febrile seizures. Pediatr Neurol 1999;20(4):270-3.

Winawer M, Hesdorffer D. Turning on the heat: the search for febrile seizure genes. Neurology 2004; 63(10):1770-1.

Wu ZQ, Sun L, Sun YH, Ren C, Jiang YH, Lv XL. Interleukin 1 beta – 511 C/T gene polymorphism and susceptibility to febrile seizures: a meta-analysis. Mol Biol Rep 2012;39(5):5401-7.

Yilmaz D, Arhan E, Yuksel D, et al. Attitudes of parents and physicians toward febrile seizures. Clin Pediatr 2008;47:856-60.

Zerr DM, Blume HK, Berg AT, et al. Nonfebrile illness seizures: a unique seizure category. Epilepsia 2005;46:952-5.

**References especially recommended by the author or editor for general reading.

In This Article

Historical note and nomenclature
Clinical manifestations
Pathogenesis and pathophysiology
Differential diagnosis
Diagnostic workup
Prognosis and complications
References cited