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By Jamil Abuzetun MD, Ribhi Hazin MD, Faisal Khan MD, Tanya Z Fischer MD PhD, and Stephen G Waxman MD PhD

Erythromelalgia is also known as or subsumes Erythermalgia and Mitchell disease. -ed.

Drs. Jamil Abuzetun, Ribhi Hazin, and Faisal Khan along with the Yale investigators including Drs Tanya Fischer and Stephen Waxman have summarized erythromelalgia in this clinical article. Recent discoveries of sodium channel mutation help our understanding of a variety of pain syndromes, including erythromelalgia. The authors further elaborate on its differential diagnosis, pathophysiology, and the current management options. Importantly, the role of aspirin in the diagnosis and management of secondary erythromelalgia has been emphasized.