Drug-induced parkinsonism is also known as or subsumes Neuroleptic-induced parkinsonism, Secondary parkinsonism, and Symptomatic parkinsonism. -ed.
Despite the development of atypical antipsychotic drugs, parkinsonism is still a common problem among patients treated with these drugs as well as with antiemetics. Because drug-induced parkinsonism frequently produces disability in the elderly, it has replaced tardive dyskinesia as the most significant neurologic complication of antipsychotic drugs in the elderly. Despite the FDA’s concern about increased mortality with these drugs, carried in a “black box warning,” these drugs are widely used in the elderly, particularly in nursing homes. Aripiprazole is now the single most commonly prescribed drug in the United States. Distinguishing purely drug induced parkinsonism from idiopathic Parkinson disease is often impossible. In this article, the author discusses phenomenology, pathophysiology, diagnosis, and treatment.