The delivery of drugs to the brain is a challenge in the treatment of CNS disorders. The major obstruction to CNS drug delivery is the blood-brain barrier, which limits the access of drugs to the brain substance. In this clinical article, Dr. K K Jain, a neurology consultant in Basel, Switzerland, describes various strategies to facilitate drug delivery to the brain in neurologic disorders. Most of these involve methods to penetrate the blood-brain barrier or to bypass it. Gene therapy is considered to be a novel form of drug delivery. Special preparation of drugs used for neurologic disorders can provide controlled and improved delivery to the site of action. The latest among these are nanoparticle-based preparations.