Diabetic neuropathies

References cited
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By Bashar Katirji MD

Airey M, Bennett C, Nicolucci A, Williams R. Aldose reductase inhibitors for the prevention and treatment of diabetic peripheral neuropathy. Cochrane Database Syst Rev 2000;(2):CD002182. PMID 10796870

Albers JW, Herman WH, Pop-Busui R, et al. Effect of prior intensive insulin treatment during the Diabetes Control and Complications Trial (DCCT) on peripheral neuropathy in type 1 diabetes during the epidemiology of diabetes interventions and complications (EDIC) study. Diabetes Care 2010;33:1090-6. PMID 20150297

Althaus J. On sclerosis of the spinal cord, including locomotor ataxy, spastic spinal paralysis and other system diseases of the spinal cord: their pathology, symptoms, diagnosis, and treatment. London: Green & Company; 1885.

Ametov AS, Barinov A, Dyck PJ, et al. The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial. Diabetes Care 2003;26(3):770-6. PMID 12610036

Anonymous. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med 1993;329(14):977-86. PMID 8366922

Anonymous. The effect of intensive diabetes therapy on measures of autonomic nervous system function in the Diabetes Control and Complications Trial (DCCT). Diabetologia 1998a;41:416-23. PMID 9562345

Anonymous. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998b;352:837-53. PMID 9742976

Archer AG, Watkins PJ, Thomas PK, Sharma AK, Payan J. The natural history of acute painful neuropathy in diabetes mellitus. J Neurol Neurosurg Psychiatry 1983;46:491-9. PMID 6875582

Asbury AK. Proximal diabetic neuropathy. Ann Neurol 1977;2:179-80. PMID 617563

Auche M. Des alterations des nerfs périphériques. Arch Med Exp Anat Pathol 1890;2:635.

Azad N, Emanuele NV, Abraira C, et al. The effects of intensive glycemic control on neuropathy in the VA cooperative study on type II diabetes mellitus (VA CSDM). J Diabetes Complications 1999;13(5-6):307-13. PMID 10765007

Boulton AJ. The diabetic foot: from art to science. The 18th Camillo Golgi lecture. Diabetologia 2004;47(8):1343-53. PMID 15309286

Boulton AJ, Malik RA, Arezzo JC, Sosenko JM. Diabetic somatic neuropathies. Diabetes Care 2004;27(6):1458-86. PMID 15161806

Boulton AJ, Vinik AI, Arezzo JC, et al. Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care 2005;28(4):956-62. PMID 15793206

Brannagan TH. Peripheral neuropathy pain: mechanisms and treatment. J Clin Neuromuscular Disease 2003;5:61-71. PMID 19078723

Bril V. Status of current clinical trials in diabetic polyneuropathy. Can J Neurol Sci 2001;28:191-8. PMID 11513337

Bril V, England J, Franklin GM, et al. Evidence-based guideline: treatment of painful diabetic neuropathy: report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Neurology 2011;76(20):1758-65. PMID 21482920

Bril V, Nyunt M, Ngo M. Limits of the sympathetic skin response in patients with diabetic polyneuropathy. Muscle Nerve 2000;23:1427-30. PMID 10951447

Bruns L. Uber neuritische Lahmungen beim Diabetes Mellitus. Berl Klin Wochenschr 1890;27:509.

Callaghan BC, Kerber K, Smith AL, Fendrick AM, Feldman EL. The evaluation of distal symmetric polyneuropathy: a physician survey of clinical practice. Arch Neurol 2012;69(3):339-45.** PMID 22083798

Calle-Pascual AL, Duran A, Benedi A, et al. A preventative foot care programme for people with diabetes with different stages of neuropathy. Diabetes Res Clin Pract 2002;57(2):111-7. PMID 12062856

Cameron N, Eaton SE, Cotter M, Tesfaye S. Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy. Diabetalogia 2001;44(11):1973-88. PMID 11719828

Caravati CM. Insulin neuritis: a case report. Va Med Mon 1933;59:745-6.

Chaudhry V, Russell J, Belzberg A. Decompressive surgery of lower limbs for symmetrical diabetic peripheral neuropathy. Cochrane Database Syst Rev 2008;(3):CD006152. PMID 18646138

Chong PS, Cros DP. Technology literature review: quantitative sensory testing. Muscle Nerve 2004;29(5):734-47. PMID 15116380

Clayburgh RH, Beckenbaugh RD, Dobyns JH. Carpal tunnel release in patients with diffuse peripheral neuropathy. J Hand Surg 1987;12A:380-3. PMID 3035004

Cocito D, Ciaramitaro P, Isoardo G. Intravenous immunoglobulin as first treatment in diabetics with concomitant distal symmetric axonal polyneuropathy and CIDP. J Neurol 2002;249:719-22. PMID 12111305

Coppack SW, Watkins PJ. The natural history of diabetic femoral neuropathy. Q J Med 1991;79:307-13. PMID 1852856

Donaghy M. Diabetic proximal neuropathy: therapy and prognosis. Q J Med 1991;79:287-8. PMID 1852854

Duchen LW, Anjorin A, Watkins PJ, Mackay JD. Pathology of autonomic neuropathy in diabetes mellitus. Ann Int Med 1980;92:301-3. PMID 6243893

Dyck PJ, Davies JL, Wilson DM, Service FJ, O'Brien PC. Risk factors for severity of diabetic polyneuropathy. Diabetes Care 1999b;22:1479-86. PMID 10480512

Dyck PJ, Kratz KM, Karnes JL, et al. The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort: the Rochester Diabetic Neuropathy Study. Neurology 1993;43:817-24. PMID 8469345

Dyck PJ, Melton LJ III, O'Brien PC, Service FJ. Approaches to improve epidemiological studies of diabetic neuropathy: insights from the Rochester Diabetic Neuropathy Study. Diabetes 1997;46(Suppl 2):S5-8. PMID 9285491

Dyck PJ, Norell JE, Dyck PJ. Microvasculitis and ischemia in diabetic lumbosacral radiculoplexus neuropathy. Neurology 1999a;53:2113-21. PMID 10599791

Dyck PJ, Norell JE, Dyck PJ. Methylprednisolone may improve lumbosacral radiculoplexus neuropathy. Can J Neurol Sci 2001;28:224-7. PMID 11513340

Dyck PJ, Windebank AJ. Diabetic and nondiabetic lumbosacral radiculoplexus neuropathies: new insights into pathophysiology and treatment. Muscle Nerve 2002;25(4):477-91. PMID 11932965

Edwards JL, Vincent AM, Cheng HT, Feldman EL. Diabetic neuropathy: mechanisms to management. Pharmacol Ther 2008;120(1):1-34. PMID 18616962

Ejskjaer N, Zanone MM, Peakman M. Autoimmunity in diabetic autonomic neuropathy: does the immune system get on your nerves. Diabet Med 1998;15:723-9. PMID 9737800

England JD, Gronseth GS, Franklin G, et al. Practice Parameter: evaluation of distal symmetric polyneuropathy: role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review). Report of the American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, and American Academy of Physical Medicine and Rehabilitation. Neurology 2009;72(2):177-84. PMID 19056667

Feldman EL, Sullivan KA, Stevens MJ. Polyolpathway: aldose reductase inhibitors - hope for the future. In: Gries FA, Cameron NE, Low PA, Ziegler D, editors. Textbook of Diabetic Neuropathy. Stuttgart: Thieme,2003:112-5.

Forrest KY, Maser RE, Pambianco G, Becker DJ, Orchard TJ. Hypertension as a risk factor for diabetic neuropathy. Diabetes Care 1997;46:665-70. PMID 9075809

Gaede P, Vedel P, Parving HH, Pedersen O. Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno 2 randomised study. Lancet 1999;353(9153):617-22. PMID 10030326

Galer BS. Neuropathic pain of peripheral origin: advances in pharmacologic treatment. Neurology 1995;45:S17-25. PMID 8538882

Gibbons CH, Freeman R. Treatment-induced diabetic neuropathy: a reversible painful autonomic neuropathy. Ann Neurol 2010;67(4):534-41. PMID 20437589

Gorson KC, Ropper AH, Adelman LS, Weinberg DH. Influence of diabetes mellitus on chronic inflammatory demyelinating polyneuropathy. Muscle Nerve 2000;23:37-43. PMID 10590404

Greco D, Gambina F, Pisciotta M, Abrignani M, Maggio F. Clinical characteristics and associated comorbidities in diabetic patients with cranial nerve palsies. J Endocrinol Invest 2012;35(2):146-9. PMID 21399393

Gregersen G. Variations in motor conduction velocity produced by acute changes of the metabolic state in diabetic patients. Diabetologia 1968;4:273-7. PMID 5738367

Gries FA, Cameron NE, Low PA, Ziegler D, editors. Textbook of diabetic neuropathy. Stuttgart, Germany: Thieme, 2003.

Griffin JW, McArthur JC, Polydefkis M. Assessment of cutaneous innervation by skin biopsies. Curr Opin Neurol 2001;14(5):655-9. PMID 11562579

Herrmann DN, Griffin JW, Hauer P, Cornblath DR, McArthur JC. Epidermal nerve fiber density and sural nerve morphometry in peripheral neuropathies. Neurology 1999;53(8):1634-40. PMID 10563605

Hyllienmark L, Golster H, Samuelssoh U, Ludvigsson J. Nerve conduction defects are retarded by tight metabolic control in type 1 diabetes. Muscle Nerve 2001;24:240-6. PMID 11180207

Jaradeh SS, Prieto TE, Lobeck LJ. Progressive polyradiculoneuropathy in diabetes: correlation of variables and clinical outcome after immunotherapy. J Neurol Neurosurg Psychiatry 1999;67:607-12. PMID 10519866

Kennedy W, Wendelschafer-Crabb G. Unmyelinated nerves: skin biopsy and skin blister methods. In: Gries FA, Cameron NE, Low PA, Ziegler D, editors. Textbook of Diabetic Neuropathy. Stuttgart, Germany: Thieme, 2003:194-8.

Kluding PM, Pasnoor M, Singh R, et al. The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy. J Diabet Complications 2012;26(5):424-9. PMID 22717465

Kraus WM. Involvement of the peripheral neurons in diabetes mellitus. Arch Neurol Psychiatry 1922;7:202.

Krendel DA, Costigan DA, Hopkins LC. Successful treatment of neuropathies in patients with diabetes mellitus. Arch Neurol 1995;52:1053-61. PMID 7487556

Lasker RD. The diabetes control and complications trial. Implications for policy and practice. N Engl J Med1993;329(14):1035-6. PMID 8366905

Lauria G, Bakkers M, Schmitz C, et al. Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study. J Peripher Nerv Syst 2010;15(3):202-7. PMID 21040142

Lee CC, Perkins BA, Kayaniyil S, et al. Peripheral neuropathy and nerve dysfunction in individuals at high risk for type 2 diabetes: the PROMISE cohort. Diabetes Care 2015;38(5):793-800. PMID 25665810

Leyden E. Entzundung der peripheren Nerven. Deut Militar Zeitsch 1887;17:49.

Llewelyn JG, Thomas PK, Fonseca V, King RH, Dandona P. Acute painful diabetic neuropathy precipitated by strict glycaemic control. Acta Neuropathol 1986;72(2):157-63. PMID 3825515

Llewelyn JG, Thomas PK, King RH. Epineurial microvasculitis in proximal diabetic neuropathy. J Neurol 1998;245:159-65. PMID 9553846

Low PA. Laboratory evaluation of autonomic function. In: Low PA, editor. Clinical autonomic disorders. 2nd ed. New York: Lippincott-Raven, 1997:179-208.

Low PA. Testing the autonomic nervous system. Semin Neurol 2003;23:407-421. PMID 15088262

Low PA, Benrud-Larsen LM, Sletten DM, et al. Autonomic symptoms and diabetic neuropathy: a population-based study. Diabetes Care 2004;27(12):2942-7. PMID 15562211

Macaré van Maurik JF, van Hal M, van Eijk RP, Kon M, Peters EJ. Value of surgical decompression of compressed nerves in the lower extremity in patients with painful diabetic neuropathy. A randomized controlled trial. Plast Reconstr Surg 2014;134(2):325-32. PMID 24732651

Malcolm A, Camilleri M. Treatment of diabetic gastroparesis and diarrhea. In: Dyck PJ, Thomas PK, editors. Diabetic neuropathy. 2nd ed. Philadelphia: WB Saunders, 1999:517-29.

Maser RE, Steenkiste AR, Dorman JS, et al. Epidemiological correlates of diabetic neuropathy. Report from Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes 1989;38:1456-61. PMID 2620781

Massie R, Mauermann ML, Staff NP, et al. Diabetic cervical radiculoplexus neuropathy: a distinct syndrome expanding the spectrum of diabetic radiculoplexus neuropathies. Brain 2012;135(Pt 10):3074-88. PMID 23065793

Navarro X, Sutherland DE, Kennedy WR. Long-term effects of pancreatic transplantation on diabetic neuropathy. Ann Neurol 1997;42:727-36. PMID 9392572

Niakan E, Harati Y. Sympathetic skin response in diabetic peripheral neuropathy. Muscle Nerve 1988;11:261-4. PMID 3352661

Oldenburg O, Kribben A, Baumgart D, Philipp T, Erbel R, Cohen MV. Treatment of orthostatic hypotension. current opinion in pharmacology 2002;2:740-7. PMID 12482740

Panoutsopoulou IG, Wendelschafer-Crabb G, Hodges JS, Kennedy WR. Skin blister and skin biopsy to quantify epidermal nerves: a comparative study. Neurology 2009;72(14):1205-10. PMID 19092108

Parisi TJ, Mandrekar J, Dyck PJ, Klein CJ. Meralgia paresthetica: relation to obesity, advanced age, and diabetes mellitus. Neurology 2011;77(16):1538-42. PMID 21975198

Perkins BA, Bril V. Diabetic neuropathy: a review emphasizing diagnostic methods. Clin Neurophysiol 2003;114(7):1167-75. PMID 12842711

Pirart J. Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients between 1947 and 1973. Diabetes Care 1978;1:168-88, 252-63.

Pittenger GL, Ray M, Burcus NI, et al. Intraepidermal nerve fibers are indicators of small-fiber neuropathy in both diabetic and nondiabetic patients. Diabetes Care 2004;27(8):1974-9. PMID 15277426

Polydefkis M, Griffin JW, McArthur J. New insights into diabetic polyneuropathy. JAMA 2003;290(10):1371-6. PMID 12966130

Pryce TD. On diabetic neuritis with a clinical and pathological description of three cases of diabetic pseudo-tabes. Brain 1893;16:416.

Reichard P, Nilsson BY, Rosenqvist U. The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus. N Engl J Med 1993;329:304-9. PMID 8147960

Rosoklija GB, Dwork AJ, Younger DS, Karlikaya G, Latov N, Hays AP. Local activation of the complement system in endoneurial microvessels of diabetic neuropathy. Acta Neuropathol 2000;99(1):55-62. PMID 10651028

Said G, Goulon-Goeau C, Lacroix C, Moulonguet A. Nerve biopsy findings in different patterns of proximal diabetic neuropathy. Ann Neurol 1994;35:559-69. PMID 8179302

Sampson MJ, Wilson S, Karagiannis P, Edmonds M, Watkins PJ. Progression of diabetic autonomic neuropathy over a decade in insulin-dependent diabetics. Q J Med 1990;75(278):635-46. PMID 2217668

Schmidt RE. Diabetic autonomic neuropathy. In: Gries FA, Cameron NE, Low PA, Ziegler D, editors. Textbook of Diabetic Neuropathy. Stuttgart-New York: Thieme, 2003:87-91.

Sharma KR, Cross J, Ayyar DR, Martinez-Arizala A, Bradley WG. Diabetic demyelinating polyneuropathy responsive to intravenous immunoglobulin therapy. Arch Neurol 2002;59(5):751-7. PMID 12020256

Simmons Z, Feldman EL. Update on diabetic neuropathy. Curr Opin Neurol 2002;15(5):595-603. PMID 12352003

Smith AG, Russell J, Feldman EL, et al. Lifestyle intervention for pre-diabetic neuropathy. Diabetes Care 2006:29(6);1294-9. PMID 16732011

Stewart JD. Diabetic truncal neuropathy: topography of the sensory deficit. Ann Neurol 1989;25:233-8. PMID 2729914

Stewart JD, Freeman R. Quantitative sensory testing. In: Brown WF, Bolton CF, Aminoff MJ, editors. Neuromuscular Function and Disease. Philadelphia: W.B.Saunders, 2002:131-43.

Stewart JD, McKelvey R, Durcan L, Carpenter S, Karpati G. Chronic inflammatory demyelinating polyneuropathy (CIDP) in diabetics. J Neurol Sci 1996;142:59-64. PMID 8902721

Tesfaye S, Boulton AJ, Dyck PJ, et al. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care 2010;33(10):2285-93. PMID 20876709

Tesfaye S, Stevens LK, Stephenson JM, et al. Prevalence of diabetic peripheral neuropathy and its relation to glycaemic control and potential risk factors: the EURODIAB IDDM Complications Study. Diabetologia 1996;39(11):1377-84. PMID 8933008

Thomas PK. Classification, differential diagnosis, and staging of diabetic peripheral neuropathy. Diabetes 1997;46(Suppl 2):S54-7. PMID 9285500

Ubogu EE, Benatar M. Electrodiagnostic criteria for carpal tunnel syndrome in axonal polyneuropathy. Muscle Nerve 2006;33(6):747-52. PMID 16502422

Valdivia Valdivia JM, Weinand M, Maloney CT Jr, Blount AL, Dellon AL. Surgical treatment of superimposed, lower extremity, peripheral nerve entrapments with diabetic and idiopathic neuropathy. Ann Plast Surg 2013;70(6):675-9. PMID 23673565

Valk GD, Grootenhuis PA, vanEijk TThM, Bouter LM, Bertelsmann FW. Methods for assessing diabetic polyneuropathy: validity and reproducibility of the measurement of sensory symptom severity and nerve function tests. Diab Res Clin Pract 2000;47:87-95. PMID 10670907

Vincent AM, Hinder LM, Pop-Busui R, Feldman EL. Hyperlipidemia: a new therapeutic target for diabetic neuropathy. J Peripher Nerv Syst 2009;14(4):257-67. PMID 20021567

Vinik A. CLINICAL REVIEW: Use of antiepileptic drugs in the treatment of chronic painful diabetic neuropathy. J Clin Endocrinol Metab 2005;90(8):4936-45. PMID 15899953

Vinik AI, Maser RE, Mitchell BD, Freeman R. Diabetic autonomic neuropathy. Diabetes Care 2003;26(5):1553-81. PMID 12716821

Vinik AI, Mehrabyan A. Diabetic neuropathies. Med Clin North Am 2004;88(4):947-99. PMID 15308387

Vinik AI, Ziegler D. Diabetic cardiovascular autonomic neuropathy. Circulation 2007;115(3):387-97. PMID 17242296

Watson CP, Watt-Watson JH. Treatment of neuropathic pain: focus on antidepressants, opioids and gabapentin. Pain Res Manage 1999;4:168-78.

Weston PJ, Gill GV. Is undetected autonomic dysfunction responsible for sudden death in Type 1 diabetes mellitus. The ‘dead in bed’ syndrome revisited. Diabet Med 1999;16(8):626-31. PMID 10477206

Wilbourn AJ. Diabetic entrapment and compression neuropathies. In: Dyck PJ, Thomas PK, editors. Diabetic neuropathy. 2nd ed. Philadelphia: WB Saunders, 1999:481-508.

Wright RA, Kaufmann HC, Perera R, et al. A double-blind, dose-response study of midodrine in neurogenic orthostatic hypotension. Neurology 1998;51:120-4. PMID 9674789

Yang CC, Bradley WG. Treatment of diabetic sexual dysfunction and cystopathy. In: Dyck PJ, Thomas PK, editors. Diabetic neuropathy. 2nd ed. Philadelphia: WB Saunders, 1999:530-40.

Yuen KC, Baker NR, Rayman G. Treatment of chronic painful diabetic neuropathy with isosorbide dinitrate spray: a double-blind placebo-controlled crossover study. Diabetes Care 2002;25(10):1699-703. PMID 12351464

Zhang WY, Li Wan Po A. The effectiveness of topically applied capsaicin: a meta-analysis. Eur J Clin Pharmacol 1994:45; 517-522. PMID 7995318

Ziegler D, Reljanovic M, Mehnert H, Gries FA. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. Exp Clin Endocrinol Diabetes 1999;107(7):421-30. PMID 10595592

Zilliox L, Peltier AC, Wren PA, et al. Assessing autonomic dysfunction in early diabetic neuropathy: the Survey of Autonomic Symptoms. Neurology 2011;76(12):1099-105. PMID 21422460

Zochodne DW. Diabetes and the plasticity of sensory neurons. Neurosci Lett 2015;596:60-5. PMID 25445357

Zochodne DW, Murray MM, van der Sloot P, Riopelle RJ. Distal tibial mononeuropathy in diabetic and nondiabetic rats reared on wire cages: an experimental entrapment neuropathy. Brain Res 1995;698:130-6. PMID 8581471

**References especially recommended by the author or editor for general reading.

In This Article

Historical note and nomenclature
Clinical manifestations
Clinical vignette
Differential diagnosis
Diagnostic workup
Prognosis and complications
References cited