Congenital cytomegalovirus

Introduction
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By Raymond P Roos MD

Congenital cytomegalovirus is also known as or subsumes Cytomegalic inclusion disease, Intrauterine cytomegalovirus infection, and Prenatal cytomegalovirus. -ed.

Cytomegalovirus (CMV) is a ubiquitous agent responsible for most intrauterine infections. Besides well-known symptoms and findings such as hearing loss and microcephaly, congenital cytomegalovirus infection can also underlie certain cerebral anomalies and static leukodystrophies. In this update, Drs. Elena Grebenciucova and Raymond Roos of the University of Chicago, discuss uncommon presentations of asymptomatic congenital cytomegalovirus, predicted outcomes of congenital multi-strain cytomegalovirus infection, and updates on potential cytomegalovirus vaccines.

Key Points

  • Cytomegalovirus is the most common infection of the developing brain.
  • Congenital cytomegalovirus infection can cause a host of cerebral abnormalities, including calcifications, ventriculomegaly, white matter lesions, cortical atrophy, and cortical migration abnormalities.
  • Affected children can have neurologic impairments that range from sensorineural hearing loss to profound mental and motor deficits.

In This Article

Introduction
Historical note and nomenclature
Clinical manifestations
Clinical vignette
Etiology
Pathogenesis and pathophysiology
Epidemiology
Prevention
Differential diagnosis
Diagnostic workup
Prognosis and complications
Management
Pregnancy
Anesthesia
References cited
Contributors