Coenzyme Q10

Historical note and nomenclature
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By K K Jain MD

Coenzyme Q10 (ubiquinone), a vitamin, was discovered in 1957 by Frederick Crane at Purdue University in Indiana. Four years later, Peter Mitchell of the University of Edinburgh, figured out how coenzyme Q10 produces energy at the cellular level and won the Nobel Prize for chemistry for this discovery in 1978. By the mid-1960s, Japanese researchers recognized that coenzyme Q10 concentrated in the myocardium. In the early 1980s, the first study of coenzyme Q10 was conducted in the treatment of cardiomyopathy. It is currently under investigation for the treatment of neurodegenerative disorders. Although not yet approved by the FDA, the product is available from health food stores. Idebenone, a synthetic analog of coenzyme Q10, has been tested in phase III clinical trials in the treatment of neurodegenerative diseases but has not been approved for use in any of these in the United States. In 2008, Health Canada approved Catena (a proprietary preparation of idebenone) for use in the symptomatic management of patients with Friedreich ataxia on the basis of the promising nature of the clinical evidence. Market authorization was issued with a condition for need of a confirmatory study.