Cluster headache

Introduction
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By Peter J Goadsby MD PhD

Cluster headache is also known as or subsumes Ciliary neuralgia, Hemicrania periodic neuralgiform, Histaminic cephalalgia, Migrainous neuralgia, Sphenopalatine ganglion neuralgia, and Vidian neuralgia. -ed.

Key points

  • Cluster headache is a relatively common, very severe form of primary headache that belongs to the family of trigeminal autonomic cephalalgias.
  • Cluster headache involves dysfunction of central nervous system elements concerned with pain control and with links to circadian and circannual mechanisms.
  • Acute cluster headache can be treated with oxygen, intranasal triptans (sumatriptan and zolmitriptan), and injected sumatriptan.
  • Medicines or strategies useful in the preventive management of cluster headache include verapamil, lithium, corticosteroids, topiramate, and melatonin.

In This Article

Introduction
Historical note and nomenclature
Clinical manifestations
Clinical vignette
Etiology
Pathogenesis and pathophysiology
Epidemiology
Prevention
Differential diagnosis
Diagnostic workup
Prognosis and complications
Management
Pregnancy
Anesthesia
References cited
Contributors