Carpal tunnel syndrome is the most common entrapment neuropathy with a prevalence of about 270 per 100,000. The etiology is compression of the median nerve in the carpal tunnel. Clinical manifestations consist of intermittent pain, numbness, and tingling in the fingers that is dependent on the position of the hand and wrist and commonly associated with subjective weakness of grip. Diagnosis is made on the basis of clinical complaints and electrodiagnostic studies. Treatment is conservative or surgical depending on the severity of the symptoms. Data on carpal tunnel syndrome in pregnancy reveal that about half of the patients remain symptomatic at 6 months after delivery. Endoscopic carpal tunnel release supposedly produces less scarring than open release, but is more expensive and precludes visualization of the median nerve proper. Controversy continues about which surgical procedure is the best. In this clinical summary update, Mamatha Pasnoor MD, Assistant Professor of Neurology at the University of Kansas Medical Center, reports that ultrasound is another useful emerging tool for evaluation of carpal tunnel syndrome and discusses novel procedures described in the literature.