Balo concentric sclerosis is also known as or subsumes Leukoencephalitis periaxialis, Marburg encephalitis periaxialis scleroticans, and Schilder encephalitis periaxialis diffusa. -ed.
Balo concentric sclerosis is often a distinct demyelinating syndrome. Dr. Kaufman argues that no clear evidence differentiates Balo concentric sclerosis from other acute, aggressive forms of multiple sclerosis. He discusses how the spectrum of Balo concentric sclerosis has changed with the discovery of nonfatal cases by magnetic resonance imaging. In addition, Dr. Kaufman describes its spectrum of symptoms and provides the current concepts behind the formation of its rings. In this update, he speculates that much about the mechanism of tissue destruction in multiple sclerosis may be inferred from pathological observations in Balo concentric sclerosis.