Acute inflammatory demyelinating polyradiculoneuropathy

Introduction
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By Betty Soliven MD

Acute inflammatory demyelinating polyradiculoneuropathy is also known as or subsumes Acute motor-sensory axonal neuropathy and Guillain-Barré syndrome. -ed.

Acute inflammatory demyelinating polyradiculoneuropathy is the most frequent pattern of Guillain-Barré syndrome encountered in North America and Europe. In this review, Dr. Soliven of the University of Chicago explains the clinical features, criteria for diagnosis, advances in the pathogenesis, and treatment of acute inflammatory demyelinating polyradiculopathy. In addition, variants of Guillain-Barré syndrome and related disorders are discussed briefly. This update includes some recent studies on biological markers in this disorder.

Key Points

  • Acute inflammatory demyelinating polyradiculoneuropathy is the most frequent pattern of Guillain-Barré syndrome encountered in North America and Europe.
  • Molecular mimicry and ganglioside antibodies play an important role in the pathogenesis of some variants of Guillain-Barré syndrome (eg, acute motor axonal neuropathy).

In This Article

Introduction
Historical note and nomenclature
Clinical manifestations
Clinical vignette
Etiology
Pathogenesis and pathophysiology
Epidemiology
Differential diagnosis
Diagnostic workup
Prognosis and complications
Management
Pregnancy
Anesthesia
References cited
Contributors